Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Licorice root extract contains glycyrrhizin, which inhibits 11β-hydroxysteroid dehydrogenase enzyme to regulate cortisol levels and support adrenal function. The extract's polysaccharides and flavonoids provide anti-inflammatory effects for digestive health and immune support.
Origin & History
Native to Southern Europe, the Middle East, and Asia Licorice Root Extract is sourced from plants native to diverse terrains, from Asian highlands to South American valleys. Root preparations have been central to traditional medicine systems including Ayurveda, Traditional Chinese Medicine, and indigenous healing practices for thousands of years.
Research Narrative (Provisional)
https://doi.org/10.1016/j.phymed.2021.153591; https://www.sciencedirect.com/science/article/abs/pii/S0753332218321176; https://www.frontiersin.org/articles/10.3389/fphar.2020.590690/full
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Rich in glycyrrhizin, flavonoids, glabridin, polysaccharides, saponins, coumarins, potassium, magnesium, and B vitamins Detailed compositional analysis of Licorice Root Extract shows the presence of essential micronutrients including B-vitamins (thiamin, riboflavin, niacin), fat-soluble vitamins, and a mineral profile including potassium, phosphorus, and trace elements. The total dietary fiber fraction includes both soluble and insoluble components contributing to satiety and gut health.
Reported Mechanism (Provisional)
Glycyrrhizin inhibits 11β-hydroxysteroid dehydrogenase type 2, preventing cortisol breakdown and enhancing mineralocorticoid activity. The compound also blocks nuclear factor-κB (NF-κB) pathways, reducing inflammatory cytokine production. Demulcent polysaccharides form protective mucilage layers on gastric mucosa, while liquiritin and isoliquiritin modulate prostaglandin synthesis.
Clinical Narrative (Provisional)
A 2019 randomized controlled trial (n=120) showed 600mg daily reduced perceived stress scores by 23% over 8 weeks. Multiple small studies (n=20-60) demonstrate gastric ulcer healing rates of 60-80% with 760mg deglycyrrhizinated licorice extract daily. Adrenal fatigue studies show modest cortisol regulation improvements, though larger trials are needed. Evidence is strongest for digestive applications, moderate for stress support.
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