Leaf & Herb · Other

Isatis Root (Ban Lan Gen)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Isatis root (Isatis tinctoria) contains indigo and indirubin compounds that modulate immune cell activity and inhibit viral replication. These bioactive alkaloids work by suppressing inflammatory cytokines while enhancing natural killer cell function.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryLeaf & Herb

GroupOther

Public Score StatusProvisional Moderate

Primary KeywordIsatis root benefits

Isatis Root close-up macro showing natural texture and detail — rich in antiviral, immunomodulatory, anti-inflammatory

Isatis Root (Ban Lan Gen) — botanical close-up

Reported Benefits (Provisional)

Supports immune function by enhancing the body's natural defenses

This strengthens the immune response against infections. - Exhibits antiviral properties by inhibiting viral replication. This can reduce the severity and duration of viral infections. - Contains anti-inflammatory compounds that reduce inflammation. This can alleviate symptoms of inflammatory conditions like arthritis. - Supports respiratory health by soothing mucous membranes. This can relieve symptoms of respiratory infections like coughs and colds. - Enhances liver function by promoting detoxification processes. This aids in the efficient removal of toxins from the body. - Contains antioxidants that combat oxidative stress. This supports overall cellular health and reduces the risk of chronic diseases. - May improve skin health by reducing inflammation and oxidative damage. This can lead to clearer, healthier skin.

Origin & History

Natural habitat

Isatis root, also known as Ban Lan Gen, is derived from the plant Isatis tinctoria, native to Central and Western Asia. The root is harvested, dried, and often ground into powder for use in traditional medicine.

“Isatis root has been used in Traditional Chinese Medicine for centuries, primarily for its antiviral and immune-boosting properties. It is a staple in herbal formulations for colds and flu.”Traditional Medicine

Research Narrative (Provisional)

Preliminary studies, including in vitro and animal research, suggest antiviral and anti-inflammatory effects. More human clinical trials are needed to confirm these benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains glucosinolates, which are sulfur-containing compounds. - Rich in flavonoids, which are known for their antioxidant properties. - Provides essential oils that contribute to its therapeutic effects.

Reported Mechanism (Provisional)

Mechanism of Action

Isatis root's primary compounds indigo and indirubin inhibit nuclear factor-kappa B (NF-κB) signaling pathways, reducing pro-inflammatory cytokine production including TNF-α and IL-6. The alkaloids also enhance interferon production and natural killer cell cytotoxicity. Additionally, indirubin demonstrates antiviral activity by blocking viral RNA polymerase and preventing viral protein synthesis.

Clinical Narrative (Provisional)

Limited clinical research exists for Isatis root, with most evidence from small-scale traditional medicine studies and in vitro research. A few preliminary trials with 50-80 participants suggested reduced duration of upper respiratory symptoms by 1-2 days compared to placebo. Laboratory studies demonstrate antiviral activity against influenza and herpes viruses, but human efficacy data remains insufficient. Most safety data comes from traditional use rather than controlled clinical trials.

Also Known As

Isatis tinctoriaWoad rootDyer's woad rootBlue dye rootEuropean woadBLGRadix Isatidis

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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