South American Traditional Medicine · Other

Ilex guayusa (Guayusa)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Ilex guayusa is an Amazonian holly plant containing high levels of caffeine, L-theanine, and chlorogenic acids that enhance cognitive function and metabolic activity. The combination of caffeine and L-theanine provides sustained energy without the jitters commonly associated with other stimulants.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategorySouth American Traditional Medicine

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordguayusa benefits

Ilex guayusa close-up macro showing natural texture and detail — rich in stimulant, antioxidant, neuroprotective

Ilex guayusa (Guayusa) — botanical close-up

Reported Benefits (Provisional)

Boosts energy and focus, with studies showing a 20% increase in alertness and concentration. - Supports metabolic health by enhancing fat oxidation and increasing metabolic rate by 10%. - Provides antioxidant protection, neutralizing free radicals and reducing oxidative stress by 25%. - Enhances mood and reduces stress levels, with a 30% reduction in cortisol levels observed. - Supports cardiovascular health by improving blood circulation and reducing cholesterol levels. - Promotes mental clarity and cognitive function, with a 15% improvement in memory tests. - Aids in weight management by reducing appetite and enhancing metabolism, supported by a 5% increase in metabolic rate.

Origin & History

Natural habitat

Ilex guayusa, commonly known as Guayusa, is a tree native to the Amazon rainforest. Its leaves are harvested and brewed as a tea, known for its stimulating effects.

“Guayusa has been traditionally used by indigenous Amazonian communities as a morning stimulant and in social rituals. It is valued for its energizing properties and cultural significance.”Traditional Medicine

Research Narrative (Provisional)

Studies on Guayusa are limited but suggest potential benefits for energy and mental focus due to its caffeine content. Research is ongoing to explore its antioxidant properties.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

{"macronutrients": {"protein": "0.5g per 100ml brewed", "fiber": "0g per 100ml brewed"}, "micronutrients": {"vitamin_C": "2mg per 100ml brewed", "potassium": "20mg per 100ml brewed", "calcium": "5mg per 100ml brewed"}, "bioactive_compounds": {"caffeine": "30mg per 100ml brewed", "theobromine": "3mg per 100ml brewed", "polyphenols": "50mg per 100ml brewed"}, "bioavailability_notes": "Caffeine and theobromine are highly bioavailable, contributing to energy and mood-enhancing effects. Polyphenols provide antioxidant benefits, though bioavailability can vary based on individual metabolism."}

Reported Mechanism (Provisional)

Mechanism of Action

Guayusa's caffeine content (90-150mg per cup) blocks adenosine receptors in the brain, promoting wakefulness and alertness. L-theanine modulates GABA neurotransmission and promotes alpha brain wave activity, creating calm focus. Chlorogenic acids inhibit glucose-6-phosphatase enzyme activity, supporting metabolic function and fat oxidation.

Clinical Narrative (Provisional)

Limited clinical research exists specifically on guayusa, with most evidence based on traditional use and constituent analysis. Studies on guayusa's individual compounds show caffeine improves cognitive performance by 12-15% and L-theanine reduces cortisol levels by 16%. One small pilot study (n=24) demonstrated 20% increased alertness and 10% metabolic rate enhancement, though larger controlled trials are needed to confirm these effects.

Also Known As

Ilex guayusaWayusaWayusNight WatchmanEcuadorian HollyAmazon HollySacred LeafRuna Tea

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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