Nootropic & Cognitive · Compound

Fasoracetam

Provisional Moderate Scorenootropic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Fasoracetam is a synthetic racetam nootropic that enhances cognitive function by modulating AMPA receptors and metabotropic glutamate receptors (mGluR). It influences GABA and glutamate neurotransmitter systems to improve memory, learning, and attention while potentially reducing ADHD symptoms.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNootropic & Cognitive

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordfasoracetam benefits

Fasoracetam close-up macro showing natural texture and detail — rich in nootropic, cognitive enhancer, ampa modulator

Fasoracetam — botanical close-up

Reported Benefits (Provisional)

Enhances cognitive function by modulating neurotransmitter systems, leading to improved memory and learning. This results in quicker information processing and recall. - Reduces symptoms of ADHD by influencing glutamate and GABA pathways, which are critical for attention and focus. This can lead to improved concentration and reduced hyperactivity. - Supports mood stabilization by modulating serotonin and dopamine receptors, which are involved in emotional regulation. This results in a more balanced emotional state and reduced anxiety. - Enhances stress resilience by modulating the stress hormone cortisol, leading to improved mood and reduced anxiety. This helps maintain mental clarity under pressure. - Supports neuroprotection by reducing oxidative stress and inflammation in the brain. This protective effect may contribute to long-term brain health. - Increases motivation and drive by influencing dopamine pathways, which are linked to reward and pleasure. This can lead to greater productivity and goal achievement. - Enhances learning ability by promoting neurogenesis, the formation of new neurons. This process is vital for adapting to new information and environments.

Origin & History

Natural habitat

Fasoracetam is a synthetic compound belonging to the racetam family, originally developed in Japan as a treatment for vascular dementia. It is produced through a series of chemical reactions that modify the pyrrolidone nucleus, characteristic of racetams.

“Initially developed in the 1990s for dementia treatment, fasoracetam has gained popularity in the nootropic community for its cognitive-enhancing properties.”Traditional Medicine

Research Narrative (Provisional)

Fasoracetam has been studied in animal models and small human trials, showing promise in cognitive enhancement and ADHD symptom reduction. Further large-scale RCTs are needed to confirm these effects.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Synthetic compound with no caloric or macronutrient content. - Primarily acts on neurotransmitter systems rather than providing nutritional value. - Interacts with glutamate, GABA, and acetylcholine pathways.

Reported Mechanism (Provisional)

Mechanism of Action

Fasoracetam acts as a positive allosteric modulator of AMPA receptors and metabotropic glutamate receptors, particularly mGluR1 and mGluR5. It enhances glutamatergic transmission while modulating GABAergic activity through upregulation of GABA-B receptors. The compound also influences the cholinergic system by increasing acetylcholine release in the hippocampus.

Clinical Narrative (Provisional)

Human clinical trials on fasoracetam remain limited, with most evidence from small-scale studies on ADHD populations. One phase II trial examined 30 adolescents with ADHD and glutamatergic gene mutations, showing modest improvements in attention scores. Animal studies demonstrate enhanced learning and memory formation, but human cognitive enhancement data is primarily anecdotal. Larger randomized controlled trials are needed to establish definitive therapeutic benefits.

Also Known As

(5R)-5-(piperidine-1-carbonyl)pyrrolidin-2-oneLAM-105NFC-1NS-105Fasoracetam hydrate5-(Piperidine-1-carbonyl)pyrrolidin-2-one

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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