Extract & Compound · Compound

Diindolylmethane (DIM)

Provisional Strong Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Diindolylmethane (DIM) is a bioactive compound formed when indole-3-carbinol from cruciferous vegetables is digested, primarily supporting hormonal balance through estrogen metabolism modulation. DIM promotes the conversion of estrogen to beneficial 2-hydroxyestrone while reducing harmful 16α-hydroxyestrone metabolites.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Strong

Primary KeywordDIM supplement benefits

Diindolylmethane close-up macro showing natural texture and detail — rich in estrogen modulator, anti-androgenic, antioxidant

Diindolylmethane (DIM) — botanical close-up

Reported Benefits (Provisional)

Diindolylmethane (DIM) supports hormonal balance by modulating estrogen metabolism, promoting healthy estrogen levels. This balance is crucial for reproductive health. - It exhibits anti-cancer properties, particularly against hormone-sensitive cancers, by inhibiting cell proliferation. Studies show a 50% reduction in tumor growth in some models. - DIM enhances detoxification by supporting liver enzyme activity, aiding in the elimination of toxins. - It supports immune health by modulating immune responses, enhancing the body's ability to fight infections. - DIM promotes weight management by influencing fat metabolism, helping to maintain a healthy body composition. - It boosts skin health by reducing acne and improving skin clarity, offering a natural solution for clearer skin. - DIM supports mood balance by influencing neurotransmitter activity, which can alleviate symptoms of mood disorders.

Origin & History

Natural habitat

Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables like broccoli and cabbage. It is produced through natural metabolic processes.

“Interest in DIM emerged from studies on indole-3-carbinol and its health benefits, particularly in cancer prevention.”Traditional Medicine

Research Narrative (Provisional)

DIM has been studied in both in vitro and human trials for its role in hormone balance and cancer prevention. Its effects on estrogen metabolism are well-documented.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Derived from indole-3-carbinol in cruciferous vegetables. - Influences estrogen metabolism and hormonal balance. - Provides bioactive compounds with anti-cancer potential.

Reported Mechanism (Provisional)

Mechanism of Action

DIM modulates estrogen metabolism by promoting CYP1A1 enzyme activity, which converts estradiol to 2-hydroxyestrone, a protective estrogen metabolite. It simultaneously inhibits CYP1B1 enzyme activity, reducing production of 16α-hydroxyestrone, an estrogen metabolite associated with increased cancer risk. DIM also activates the aryl hydrocarbon receptor (AhR), triggering detoxification pathways and supporting cellular protection mechanisms.

Clinical Narrative (Provisional)

Small-scale human trials with 50-200mg daily DIM supplementation have shown improved estrogen metabolite ratios within 4-6 weeks in postmenopausal women. A 12-week study of 130 women demonstrated 75% improvement in 2:16α-hydroxyestrone ratios compared to placebo. Limited clinical evidence exists for cancer prevention, with most data coming from in vitro and animal studies. Current human research is promising but requires larger, longer-term trials to establish definitive therapeutic benefits.

Also Known As

3,3'-DiindolylmethaneDIMBis(3-indolyl)methane3,3'-MethylenediindoleDiindolmethaneI3C metaboliteCruciferous compound

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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