Amino Acid & Peptide · Compound

Dihexa

Provisional Moderate Scoreamino_acid

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Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Dihexa is a synthetic nootropic peptide derived from angiotensin IV that enhances cognitive function through hepatocyte growth factor (HGF) pathway activation. This compound promotes synaptogenesis and neurogenesis in the hippocampus, potentially improving memory formation and learning capacity.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryAmino Acid & Peptide

GroupCompound

Public Score StatusProvisional Moderate

Primary Keyworddihexa benefits

Dihexa close-up macro showing natural texture and detail — rich in neurotrophic, cognitive enhancer, synaptogenic

Dihexa — botanical close-up

Reported Benefits (Provisional)

Supports cognitive function by enhancing synaptogenesis, which strengthens connections between brain cells for improved learning and memory. - May improve symptoms of neurodegenerative diseases such as Alzheimer's by promoting neurogenesis and protecting neurons from damage. - Boosts memory retention by increasing brain-derived neurotrophic factor (BDNF), with studies showing up to 70% improvement in certain models. - Enhances mental clarity and focus by modulating acetylcholine pathways, vital for attention and processing speed. - Promotes mood stability by balancing neurotransmitter levels, reducing anxiety and depressive symptoms. - May aid recovery from traumatic brain injury by stimulating neural repair mechanisms. - Supports long-term brain health by reducing oxidative stress and inflammation in neural tissues. - Improves overall cognitive resilience, helping the brain adapt to stress and aging.

Origin & History

Natural habitat

Dihexa is a synthetic peptide developed for its potential cognitive-enhancing properties. It is synthesized through advanced peptide engineering to ensure high purity and efficacy for research purposes.

“Dihexa was developed in recent years as a potential treatment for cognitive decline, with ongoing research in neuropharmacology.”Traditional Medicine

Research Narrative (Provisional)

Preclinical studies in animals suggest Dihexa's potential in cognitive enhancement and neuroprotection. Human trials are limited and ongoing.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Composed of a unique peptide sequence. - Contains no calories, fats, or carbohydrates. - Available in oral or topical forms for research use.

Reported Mechanism (Provisional)

Mechanism of Action

Dihexa activates the hepatocyte growth factor (HGF) and its receptor c-Met, triggering downstream PI3K/Akt and MAPK signaling pathways that promote synaptic plasticity. The compound binds to the AT4 receptor subtype and enhances AMPA receptor trafficking to synapses. This mechanism stimulates dendritic spine formation, increases synaptic density, and promotes neuronal survival in hippocampal regions.

Clinical Narrative (Provisional)

Preclinical studies in rodent models demonstrate dihexa's ability to reverse cognitive deficits in Alzheimer's disease models at doses of 0.5-5 mg/kg. Research shows 10-fold improvements in spatial learning tasks and restoration of synaptic connectivity within 1-2 weeks of treatment. However, human clinical trials are extremely limited, with most evidence derived from animal studies and small-scale laboratory research. The compound remains largely experimental with insufficient data to establish therapeutic efficacy in humans.

Also Known As

N-hexanoic-Tyr-Ile-(6) aminohexanoic amidePNB-0408Hexanoyl-Tyr-Ile-Ahx-NH2Cognitive enhancement peptideNootropic peptide compoundSynthetic neurotropic factor

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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