Cognigrape (Vitis vinifera)

Cognigrape is a patented whole grape extract (Vitis vinifera) standardized from Italian red grapes, delivering a concentrated polyphenol complex. Primary bioactive compounds include total polyphenols at approximately 60-70% by weight, with the key fractions being: oligomeric proanthocyanidins (OPCs) as a dominant constituent, anthocyanins (including malvidin-3-glucoside, cyanidin-3-glucoside, peonidin-3-glucoside) contributing to the characteristic color and neuroprotective activity, and resveratrol in modest concentrations (<1%). Flavonols such as quercetin, kaempferol, and myricetin are present as glycoside conjugates. The extract also contains hydroxycinnamic acids (caffeic acid, p-coumaric acid, ferulic acid) and hydroxybenzoic acids (gallic acid, ellagic acid). At the studied dose of 250 mg per capsule, the extract delivers an estimated 150-175 mg total polyphenols per serving. Macronutrient content is negligible at supplemental doses (trace carbohydrates from grape matrix). Minerals detected in whole grape extracts include potassium, calcium, and magnesium at trace levels. Bioavailability is enhanced by the whole-grape matrix approach, which preserves the synergistic interaction between polyphenol classes; anthocyanins show rapid absorption (Tmax ~1-2 hours) with moderate bioavailability (~5-10% of ingested dose reaching systemic circulation), while OPCs demonstrate slower, more sustained absorption.