Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Cat's claw (Uncaria tomentosa) is a woody vine containing pentacyclic oxindole alkaloids that modulate immune function and reduce inflammation. These compounds inhibit nuclear factor-kappa B (NF-κB) signaling, reducing pro-inflammatory cytokine production while enhancing T-helper cell activity.
Reported Benefits (Provisional)
Origin & History
Cat's Claw, scientifically known as Uncaria Tomentosa, is a vine native to the Amazon rainforest. The bark and root are harvested and processed into extracts or teas.
Research Narrative (Provisional)
Preliminary studies and some clinical trials suggest its potential in supporting immune health and reducing inflammation, but more research is needed.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Rich in alkaloids and flavonoids. - Contains tannins and sterols. - Provides polyphenolic compounds.
Reported Mechanism (Provisional)
Cat's claw's pentacyclic oxindole alkaloids, particularly isopteropodine and pteropodine, inhibit nuclear factor-kappa B (NF-κB) transcription, reducing TNF-alpha and interleukin-1 beta production. The alkaloids also enhance T-lymphocyte proliferation and increase interleukin-2 production. Quinovic acid glycosides provide additional anti-inflammatory effects by inhibiting 5-lipoxygenase activity.
Clinical Narrative (Provisional)
A 12-week randomized controlled trial of 40 rheumatoid arthritis patients showed cat's claw extract reduced joint pain by 40% compared to placebo. Small pilot studies (20-30 participants) demonstrated 30% increases in CD4+ T-cell counts in HIV patients after 8 weeks supplementation. However, most clinical evidence comes from small trials with 6-12 week durations, limiting conclusions about long-term efficacy and optimal dosing.
Also Known As
Research updates — and 25% off your first order
Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.