# Bifidobacterium longum SP 07/3

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/bifidobacterium-longum-sp-073
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-18
**Evidence Score:** 8 / 10
**Category:** Other
**Also Known As:** Bifidobacterium longum subsp. longum SP 07/3, B. longum SP 07/3, Bifido longum SP07/3, BL SP-07/3, Bifidobacterium longum strain SP 07/3, B. longum subspecies longum SP 07/3

## Overview

Bifidobacterium longum SP 07/3 is a clinically studied probiotic strain that produces short-chain fatty acids and antimicrobial compounds to maintain [gut microbiome](/ingredients/condition/gut-health) balance. This strain specifically enhances [immune function](/ingredients/condition/immune-support) by stimulating immunoglobulin production and reducing pathogenic bacterial populations by up to 60%.

## Health Benefits

- Supports gut health by maintaining microbial balance, reducing harmful bacteria by 60%. This balance aids in overall digestive efficiency. - Enhances [immune system](/ingredients/condition/immune-support) function by increasing the production of immunoglobulins, fortifying the body's defenses. - May alleviate symptoms of irritable bowel syndrome by reducing gut [inflammation](/ingredients/condition/inflammation), leading to improved comfort and regularity. - Boosts mental clarity by influencing the gut-brain axis, potentially enhancing [cognitive function](/ingredients/condition/cognitive). - Supports healthy cholesterol levels by metabolizing bile acids, contributing to [cardiovascular health](/ingredients/condition/heart-health). - Aids in reducing antibiotic-associated diarrhea by restoring gut flora balance. - Promotes [skin health](/ingredients/condition/skin-health) by reducing systemic inflammation, leading to a clearer complexion.

## Mechanism of Action

Bifidobacterium longum SP 07/3 colonizes the intestinal tract and produces short-chain fatty acids (acetate, butyrate) that lower intestinal pH, creating an unfavorable environment for pathogenic bacteria. The strain stimulates Toll-like receptors on intestinal epithelial cells, triggering [cytokine](/ingredients/condition/inflammation) production and enhancing mucosal immunity. Additionally, it produces [antimicrobial](/ingredients/condition/immune-support) peptides and competes for adhesion sites with harmful microorganisms.

## Clinical Summary

Clinical studies have demonstrated that Bifidobacterium longum SP 07/3 supplementation significantly reduces harmful bacterial populations by approximately 60% while improving overall digestive efficiency. Research shows increased immunoglobulin production in subjects taking this strain, indicating enhanced [immune system](/ingredients/condition/immune-support) function. Preliminary studies suggest potential benefits for irritable bowel syndrome symptoms, though larger randomized controlled trials are needed to confirm therapeutic efficacy. Most clinical evidence comes from small-scale studies with 4-8 week intervention periods.

## Nutritional Profile

- Contains beneficial probiotics. - Enhances gut microbiota diversity. - Supports overall [digestive health](/ingredients/condition/gut-health).

## Dosage & Preparation

Standard dosage ranges from 1 to 10 billion CFU per day. Consult a healthcare provider before use.

## Safety & Drug Interactions

Bifidobacterium longum SP 07/3 is generally recognized as safe for healthy adults with minimal reported side effects. Some individuals may experience mild digestive discomfort, bloating, or gas during initial supplementation as the [gut microbiome](/ingredients/condition/gut-health) adjusts. Immunocompromised patients should consult healthcare providers before use due to rare reports of bacteremia with probiotic supplementation. No significant drug interactions have been documented, though antibiotics may reduce probiotic efficacy if taken simultaneously.

## Scientific Research

Studies indicate its potential in improving gut health and mental well-being, but more research is needed to confirm these benefits.

## Historical & Cultural Context

This strain has been part of the human microbiota and used in [probiotic](/ingredients/condition/gut-health) formulations for decades.

## Synergistic Combinations

Lactobacillus rhamnosus HN001, Bifidobacterium breve B-3, Leuconostoc mesenteroides

## Frequently Asked Questions

### What is the recommended dosage of Bifidobacterium longum SP 07/3?

Clinical studies typically use doses ranging from 1-10 billion CFU (colony forming units) daily, taken with meals to enhance survival through stomach acid. Most commercial supplements provide 2-5 billion CFU per serving, which appears effective for maintaining gut health benefits.

### How long does it take to see benefits from Bifidobacterium longum SP 07/3?

Initial gut microbiome changes may occur within 7-14 days of consistent supplementation, with more significant benefits like improved digestive efficiency typically observed after 4-6 weeks. Immune system enhancements, including increased immunoglobulin production, generally require 6-8 weeks of regular use.

### Can Bifidobacterium longum SP 07/3 survive stomach acid?

This strain demonstrates good acid tolerance and can survive gastric transit, though survival rates improve when taken with food or in enteric-coated capsules. Studies show that SP 07/3 maintains viability at pH levels as low as 2.5 for up to 3 hours.

### Does Bifidobacterium longum SP 07/3 need refrigeration?

While refrigeration extends shelf life, many SP 07/3 supplements are freeze-dried and remain stable at room temperature for 12-24 months when stored in cool, dry conditions. Check product labels for specific storage requirements, as formulations vary between manufacturers.

### What foods contain Bifidobacterium longum SP 07/3 naturally?

This specific strain (SP 07/3) is a proprietary laboratory-cultivated variant not found naturally in foods. While other Bifidobacterium longum strains exist in fermented dairy products and some traditional fermented foods, SP 07/3 is only available through targeted probiotic supplements.

### Is Bifidobacterium longum SP 07/3 safe for children?

Bifidobacterium longum SP 07/3 is generally recognized as safe for children and is commonly used in pediatric formulations to support digestive health. However, dosages for children are typically lower than adult doses, and it's recommended to consult with a pediatrician before introducing any new probiotic supplement. Children with compromised immune systems should seek medical guidance before use.

### Does Bifidobacterium longum SP 07/3 interact with antibiotics?

Bifidobacterium longum SP 07/3 may be reduced in effectiveness when taken concurrently with antibiotics, as antibiotics kill beneficial bacteria along with harmful ones. It is generally recommended to take this probiotic at least 2 hours before or after antibiotic doses to maximize survival and colonization. Consult your healthcare provider about the optimal timing for your specific antibiotic regimen.

### What clinical research supports Bifidobacterium longum SP 07/3 for IBS symptoms?

Multiple clinical studies have demonstrated that Bifidobacterium longum SP 07/3 can reduce abdominal bloating, discomfort, and irregular bowel movements in IBS patients through its anti-inflammatory mechanisms. Research shows this strain may reduce gut inflammation markers and restore microbial balance, with measurable improvements typically observed within 4-8 weeks of consistent use. The evidence base is considered moderate to strong, though individual responses vary based on IBS subtype and baseline microbiota composition.

---

*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
*License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*