Oil & Fat · Other

Arachidonic Acid (AA)

Provisional Moderate Scorelipid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Arachidonic acid (AA) is an omega-6 fatty acid that serves as a precursor to inflammatory mediators including prostaglandins and leukotrienes through cyclooxygenase and lipoxygenase pathways. It plays crucial roles in muscle protein synthesis, immune function, and brain development.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryOil & Fat

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordarachidonic acid benefits

Arachidonic Acid close-up macro showing natural texture and detail — rich in pro-inflammatory, immunomodulatory, neuroactive

Arachidonic Acid (AA) — botanical close-up

Reported Benefits (Provisional)

Supports muscle growth and recovery in athletes

AA enhances protein synthesis, crucial for muscle repair and growth. - Aids in maintaining joint health and reducing pain. It supports cartilage health, reducing joint discomfort. - Enhances brain function and cognitive performance. AA is vital for synaptic function, improving memory and focus. - Supports immune system health. It aids in the production of eicosanoids, crucial for immune responses. - Promotes skin health by maintaining elasticity and hydration. AA supports collagen production, reducing signs of aging. - Supports cardiovascular health by regulating blood vessel function. It helps maintain healthy blood pressure and circulation. - May improve mood and mental well-being. AA supports neurotransmitter balance, enhancing mood stability.

Origin & History

Natural habitat

Arachidonic acid (AA) is an omega-6 fatty acid found in animal products like meat and eggs. It is produced endogenously from linoleic acid and is essential for the synthesis of eicosanoids.

“AA has been recognized for its role in inflammation and muscle physiology, particularly in the context of sports nutrition and performance.”Traditional Medicine

Research Narrative (Provisional)

Research, including human trials, has shown AA's role in muscle growth and recovery. Its effects on inflammation and cardiovascular health are also being studied.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains omega-6 fatty acids, particularly AA. - Found in animal products like meat and eggs. - Essential for eicosanoid synthesis, impacting inflammation and immunity.

Reported Mechanism (Provisional)

Mechanism of Action

Arachidonic acid is metabolized by cyclooxygenase (COX) enzymes to produce prostaglandins E2 and F2α, which regulate inflammation and muscle protein synthesis. The lipoxygenase pathway converts AA to leukotrienes, affecting immune responses and vascular function. AA also directly incorporates into cell membrane phospholipids, influencing membrane fluidity and cellular signaling cascades.

Clinical Narrative (Provisional)

Small-scale studies in resistance-trained athletes show 1-1.5g daily AA supplementation for 8-12 weeks may increase lean body mass by 1-3 pounds compared to placebo. A 50-day study with 31 participants found AA supplementation enhanced anaerobic power output by 5-10%. However, most research involves small sample sizes (15-50 participants) and short durations. More large-scale, long-term trials are needed to confirm efficacy and optimal dosing.

Also Known As

5,8,11,14-eicosatetraenoic acidAAARA20:4(n-6)Icosatetraenoic acidEicosatetraenoic acidArachidonate

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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