MAJOR — Use With Caution
🔴 AVOID — Both furosemide and licorice root cause significant potassium loss. Combined use creates dangerous hypokalemia risk that can trigger cardiac arrhythmias.
Evidence level: STRONG
Both licorice root and Lasix cause your body to lose potassium. Together, potassium can drop to dangerously low levels, risking heart rhythm problems.
Licorice root causes pseudoaldosteronism with potassium wasting. Furosemide (loop diuretic) also causes significant potassium loss. The combination creates dangerous hypokalemia risk, which can cause cardiac arrhythmias.
Do NOT take licorice root supplements while on furosemide. The combined potassium-wasting effect is dangerous. DGL (deglycyrrhizinated licorice) is a safe alternative as the problematic compound has been removed.
Be consistent with how you take Furosemide relative to meals — take it with food or without food consistently each day. Licorice Root — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Muscle weakness, cramps, fatigue, irregular or rapid heartbeat, constipation, tingling/numbness. Severe hypokalemia is a medical emergency — seek immediate care if you experience heart palpitations or muscle paralysis.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Adjust the timing or quantity of Licorice Root relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
Both licorice root and Lasix cause your body to lose potassium. Together, potassium can drop to dangerously low levels, risking heart rhythm problems.
Be consistent with how you take Furosemide relative to meals — take it with food or without food consistently each day. Licorice Root — sudden large changes in diet composition can affect how your body processes many medications. Grapefruit, leafy greens, and high-fiber foods are the most common food-drug interaction culprits.
Muscle weakness, cramps, fatigue, irregular or rapid heartbeat, constipation, tingling/numbness. Severe hypokalemia is a medical emergency — seek immediate care if you experience heart palpitations or muscle paralysis.
Adjust the timing or quantity of Licorice Root relative to your medication. Maintain consistent daily intake rather than large sporadic amounts. Your pharmacist can advise on specific timing windows.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. An up-to-date list helps them make the best treatment decisions.
Or browse the full interaction database (121,000+ pairs).