MODERATE — Monitor Closely
🟡 MODERATE — CBD and Fluvoxamine mutually increase each other's levels.
Evidence level: MODERATE
CBD and fluvoxamine block different liver enzymes from each other, so both substances accumulate to higher levels than expected.
CBD inhibits CYP2D6/CYP3A4; fluvoxamine potently inhibits CYP1A2/CYP2C19. Bidirectional enzyme inhibition raises levels of both.
Use extra caution with this combination. Both are enzyme inhibitors. Start CBD at very low doses.
Take Fluvoxamine at the same time each day as prescribed. CBD Oil can be taken at any convenient time — morning with breakfast is most common. Some botanicals (St. John's Wort especially) have serotonergic activity and must NOT be combined with SSRIs. If you notice increased drowsiness or agitation, shift the botanical to a different time or discuss discontinuation with your prescriber.
OCD patients on high-dose fluvoxamine
Increased nausea, agitation, drowsiness, tremor
Discuss with your psychiatrist before starting CBD
Consider talking to your doctor about adjusting your antidepressant dose rather than adding CBD Oil. Safer supplement options for mood support include magnesium glycinate, omega-3 fish oil, or vitamin D3 — all with strong evidence and minimal drug interactions.
CBD and fluvoxamine block different liver enzymes from each other, so both substances accumulate to higher levels than expected.
Take Fluvoxamine at the same time each day as prescribed. CBD Oil can be taken at any convenient time — morning with breakfast is most common. Some botanicals (St. John's Wort especially) have serotonergic activity and must NOT be combined with SSRIs. If you notice increased drowsiness or agitation, shift the botanical to a different time or discuss discontinuation with your prescriber.
Increased nausea, agitation, drowsiness, tremor
Consider talking to your doctor about adjusting your antidepressant dose rather than adding CBD Oil. Safer supplement options for mood support include magnesium glycinate, omega-3 fish oil, or vitamin D3 — all with strong evidence and minimal drug interactions.
Discuss with your psychiatrist before starting CBD
Or browse the full interaction database (121,000+ pairs).