MODERATE — Monitor Closely
CAUTION — monitor mood
Evidence level: STRONG
Tegretol may reduce Celexa effectiveness.
Carbamazepine CYP induction may reduce citalopram levels.
Monitor for depression breakthrough.
Some SSRIs inhibit CYP enzymes that metabolize antiepileptics — fluoxetine and fluvoxamine are the biggest offenders, potentially raising levels of phenytoin or carbamazepine. Take each at their prescribed times. Monitor for signs of antiepileptic toxicity (dizziness, double vision, nausea) when adding an SSRI.
Active depression
Worsening depression
Coordinate care.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Tegretol may reduce Celexa effectiveness.
Some SSRIs inhibit CYP enzymes that metabolize antiepileptics — fluoxetine and fluvoxamine are the biggest offenders, potentially raising levels of phenytoin or carbamazepine. Take each at their prescribed times. Monitor for signs of antiepileptic toxicity (dizziness, double vision, nausea) when adding an SSRI.
Worsening depression
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Coordinate care.
Or browse the full interaction database (121,000+ pairs).