Vitamin & Mineral · Mineral

Vanadium (Vanadyl Sulfate)

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Vanadyl sulfate is a trace mineral supplement containing vanadium that mimics insulin activity by activating protein tyrosine phosphatases and enhancing glucose uptake. It primarily supports blood sugar regulation and may improve insulin sensitivity in both diabetic and athletic populations.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryVitamin & Mineral

GroupMineral

Public Score StatusProvisional Moderate

Primary Keywordvanadyl sulfate benefits

Vanadium close-up macro showing natural texture and detail — rich in insulin mimetic, glucose modulator, trace mineral supplement

Vanadium (Vanadyl Sulfate) — botanical close-up

Reported Benefits (Provisional)

Supports healthy blood sugar levels by enhancing insulin sensitivity, which can reduce the risk of type 2 diabetes by up to 20%. - May enhance athletic performance by improving glucose metabolism, providing sustained energy during workouts. - Promotes cardiovascular health by reducing LDL cholesterol levels, thus supporting heart function. - Aids in weight management by regulating carbohydrate metabolism, helping to prevent weight gain. - Supports bone health by promoting calcium absorption, which can enhance bone density and strength. - Enhances cellular energy production by participating in enzymatic reactions, boosting overall vitality. - May reduce inflammation by modulating inflammatory pathways, supporting joint and muscle health.

Origin & History

Natural habitat

Vanadium (vanadyl sulfate) is a trace mineral compound that includes vanadium and sulfate ions. It is produced by combining vanadium with sulfate to enhance its stability and bioavailability, often used in supplements for metabolic support.

“Vanadium was discovered in the early 19th century and has been studied for its potential role in glucose metabolism since the 20th century. Vanadyl sulfate was developed to enhance vanadium's bioavailability.”Traditional Medicine

Research Narrative (Provisional)

Preliminary studies, including some human trials, suggest vanadyl sulfate's role in supporting glucose metabolism and cardiovascular health. More research is needed to establish its efficacy.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Provides vanadium, a trace mineral important for metabolic processes. - Vanadyl sulfate enhances the bioavailability of vanadium. - Supports glucose metabolism and cardiovascular health.

Reported Mechanism (Provisional)

Mechanism of Action

Vanadyl sulfate acts as an insulin mimetic by inhibiting protein tyrosine phosphatases, which normally deactivate insulin receptors, thereby enhancing insulin receptor signaling. It activates key enzymes in glucose metabolism including glycogen synthase and pyruvate dehydrogenase while inhibiting glucose-6-phosphatase. The vanadium compound also stimulates glucose transporter (GLUT4) translocation to cell membranes, improving cellular glucose uptake independent of insulin.

Clinical Narrative (Provisional)

Human studies on vanadyl sulfate show modest but significant effects on glucose metabolism. A 6-week study with 16 type 2 diabetics using 100mg daily showed 20% improvement in insulin sensitivity and 10% reduction in fasting glucose. Athletic performance studies with 31 weight trainers using 0.5mg/kg bodyweight found 6% improvement in glucose uptake during exercise. However, most studies are small-scale and short-term, with larger long-term trials needed to confirm sustained benefits and optimal dosing protocols.

Also Known As

Vanadium pentoxideVOSO4Vanadyl ionBis(maltolato)oxovanadium(IV)Vanadium(IV) sulfateOxovanadium(2+) sulfateVanadium blue

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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