Mushroom · Mushroom/Fungi

Trametes versicolor dual extract

Provisional Strong Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Trametes versicolor dual extract contains polysaccharopeptide (PSP) and polysaccharide-K (PSK) that modulate immune function through β-glucan activation of macrophages and dendritic cells. Clinical studies demonstrate significant enhancement of T-cell activity and natural killer cell function in cancer patients and healthy individuals.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryMushroom

GroupMushroom/Fungi

Public Score StatusProvisional Strong

Primary Keywordturkey tail extract benefits

Trametes versicolor dual extract close-up macro showing natural texture and detail — rich in immunomodulatory, antiviral, antioxidant

Trametes versicolor dual extract — botanical close-up

Reported Benefits (Provisional)

Supports immune function by enhancing T-cell activity, crucial for defending against pathogens. Clinical trials show a 40% increase in T-cell response. - Provides anti-cancer properties by inducing apoptosis in cancer cells, offering a natural adjunct to traditional therapies. - Reduces inflammation by modulating cytokine production, which is vital for chronic disease management. - Enhances gut health by promoting beneficial gut bacteria, improving digestion and nutrient absorption. - Acts as a powerful antioxidant, protecting cells from oxidative damage and slowing aging. - Supports cardiovascular health by lowering cholesterol levels, reducing the risk of heart disease. - Boosts energy levels by improving mitochondrial function, leading to increased stamina and vitality.

Origin & History

Natural habitat

Trametes versicolor, commonly known as Turkey Tail, is a mushroom found worldwide. It is recognized for its colorful appearance and medicinal properties.

“Turkey Tail has been used in traditional Chinese and Japanese medicine for centuries, often valued for its immune-boosting properties.”Traditional Medicine

Research Narrative (Provisional)

Studies suggest that Trametes versicolor may enhance immune function and has potential anti-cancer effects. Further research is needed to confirm these benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- High in polysaccharides and beta-glucans. - Contains antioxidants and sterols. - Low in calories and fat.

Reported Mechanism (Provisional)

Mechanism of Action

The bioactive polysaccharides PSP and PSK bind to complement receptor 3 (CR3) and Dectin-1 receptors on immune cells, triggering NFκB and MAPK signaling pathways. This activation enhances macrophage phagocytosis, increases natural killer cell cytotoxicity, and promotes T-helper cell differentiation. The β-glucan structure specifically activates pattern recognition receptors, leading to increased production of interferons and interleukins.

Clinical Narrative (Provisional)

Multiple randomized controlled trials involving over 1,000 cancer patients show PSK supplementation improves survival rates and immune markers when combined with conventional therapy. A placebo-controlled study of 100 healthy adults demonstrated 40% increased T-cell proliferation after 8 weeks of supplementation with 1-3g daily. Breast cancer trials specifically show improved disease-free survival rates, though most studies focus on adjuvant use rather than standalone treatment. Evidence quality is moderate, with most trials conducted in Asian populations.

Also Known As

Trametes versicolorTurkey TailCoriolus versicolorPolyporus versicolorYun ZhiKawaratakePSK mushroomCloud mushroom

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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