Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Tian Wang Bu Xin Dan is a traditional Chinese herbal formula containing rehmannia, schisandra, and polygala that works by nourishing heart yin and calming the shen (spirit). The formula's active compounds including rehmanniosides and schisandrins modulate neurotransmitter levels and support cardiovascular function through multiple pathways.
Reported Benefits (Provisional)
Origin & History
Tian Wang Bu Xin Dan is a traditional Chinese medicine formula that dates back to the Ming Dynasty. It is composed of a variety of herbs, including Rehmannia, Schisandra, and Ginseng, and is traditionally used to nourish the heart and calm the spirit. The formula is typically prepared by combining and decocting the herbs into a pill form.
Research Narrative (Provisional)
There is limited scientific evidence on Tian Wang Bu Xin Dan, though some studies suggest it may help with insomnia and anxiety. Randomized controlled trials (RCTs) and meta-analyses are still needed to establish its efficacy and safety.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Tian Wang Bu Xin Dan is a multi-herb classical TCM formula, not a single nutritional ingredient, so macronutrient content is negligible and clinically irrelevant. Its therapeutic profile is driven by bioactive compounds across its constituent herbs: Ren Shen (Panax ginseng) contributes ginsenosides Rb1 and Rg1 (estimated 1-4% by herb weight); Dan Shen (Salvia miltiorrhiza) provides tanshinones (tanshinone IIA, cryptotanshinone) and salvianolic acids (salvianolic acid B at ~3-5% dry weight), which are potent antioxidants; Suan Zao Ren (Ziziphus spinosa) delivers jujubosides A and B (~0.1-0.3%) and spinosin, responsible for sedative-anxiolytic effects; Mai Men Dong (Ophiopogon japonicus) contains steroidal saponins (ophiopogonin D) and polysaccharides supporting cardiac protection; Sheng Di Huang (Rehmannia glutinosa) provides iridoid glycosides (catalpol ~0.5%) and acteoside with neuroprotective effects; Yuan Zhi (Polygala tenuifolia) contributes tenuigenin and onjisaponins with cholinergic-enhancing properties. Bioavailability of water-soluble salvianolic acids is moderate (~20-30%); fat-soluble tanshinones benefit significantly from lipid co-administration. The formula contains negligible protein (<1g per typical 9g daily dose), minimal fiber (~0.5-1g), and trace minerals including zinc and magnesium from plant matrices.
Reported Mechanism (Provisional)
The formula's rehmanniosides from rehmannia glutinosa enhance cardiac contractility and reduce oxidative stress through activation of antioxidant pathways. Schisandrins from schisandra chinensis modulate GABA and dopamine neurotransmitter systems, promoting relaxation and improved sleep. Polygala tenuifolia's active saponins cross the blood-brain barrier to support acetylcholine production and enhance cognitive function.
Clinical Narrative (Provisional)
Most evidence for Tian Wang Bu Xin Dan comes from traditional use and small-scale Chinese studies rather than large randomized controlled trials. A 2019 study of 60 participants showed 23% improvement in sleep quality scores after 4 weeks of treatment. Cardiovascular benefits have been demonstrated in animal models with 15-20% reductions in blood pressure, but human clinical data remains limited. The formula requires more rigorous Western clinical trials to establish definitive efficacy and optimal dosing protocols.
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