Probiotic & Fiber · Fermented/Probiotic

Saccharomyces boulardii CNCM I-745

Provisional Strong Scoreprobiotic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Saccharomyces boulardii CNCM I-745 is a probiotic yeast that produces bioactive compounds like polyamines and proteases to restore gut microbiota balance. It prevents diarrhea by inhibiting pathogenic bacteria adhesion and strengthening intestinal barrier function through enhanced tight junction proteins.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryProbiotic & Fiber

GroupFermented/Probiotic

Public Score StatusProvisional Strong

Primary KeywordSaccharomyces boulardii benefits

Saccharomyces boulardii CNCM I-745 — botanical close-up

Reported Benefits (Provisional)

Supports digestive health by balancing the gut microbiota, helping to restore beneficial bacteria after antibiotic use. - May prevent and treat various types of diarrhea, including antibiotic-associated and traveler’s diarrhea, by inhibiting pathogenic microbes. - Strengthens intestinal barrier function, reducing gut permeability and supporting nutrient absorption. - Modulates immune responses, lowering inflammation and enhancing resistance to infections. - Reduces symptoms of irritable bowel syndrome (IBS), such as bloating and discomfort, by regulating gut motility. - Produces short-chain fatty acids that nourish colon cells and improve overall gut health. - May decrease the duration of acute diarrhea in children by up to 24 hours, according to clinical studies. - Aids in the breakdown of dietary fiber, supporting regular bowel movements and digestive comfort.

Origin & History

Saccharomyces boulardii CNCM I-745 — origin

Natural habitat

Saccharomyces boulardii CNCM I-745 is a probiotic yeast isolated from tropical fruits. It is produced through fermentation and is commonly used in dietary supplements.

“Discovered in the 1920s, Saccharomyces boulardii has been used for its probiotic benefits for nearly a century, particularly in managing digestive disorders.”Traditional Medicine

Research Narrative (Provisional)

Saccharomyces boulardii CNCM I-745 has been extensively studied, with numerous RCTs demonstrating its efficacy in preventing and treating diarrhea. Meta-analyses confirm its benefits in various gastrointestinal conditions.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains live probiotic yeast cultures. - Produces bioactive compounds that support gut health. - Rich in enzymes that aid digestion.

Reported Mechanism (Provisional)

Mechanism of Action

Saccharomyces boulardii produces proteases that degrade bacterial toxins and releases polyamines that enhance intestinal epithelial cell proliferation. It competitively inhibits pathogenic bacteria adhesion to intestinal mucosa by binding to common receptor sites. The yeast stimulates secretory IgA production and increases expression of tight junction proteins like claudin-1 and occludin to strengthen intestinal barrier integrity.

Clinical Narrative (Provisional)

Multiple randomized controlled trials with 50-400 participants demonstrate Saccharomyces boulardii CNCM I-745 reduces antibiotic-associated diarrhea incidence by 57-70% when taken at 250-500mg twice daily. Meta-analyses of 31 studies show significant efficacy in preventing Clostridium difficile-associated diarrhea with NNT of 12.5. Studies in traveler's diarrhea show 40-50% reduction in symptom duration and severity. Evidence quality is considered moderate to high for diarrhea prevention, with most studies showing consistent beneficial outcomes across diverse populations.

Also Known As

Saccharomyces cerevisiae var. boulardiiS. boulardii CNCM I-745S. boulardiiProbiotic yeastBeneficial yeastFlorastor yeastTropical fruit yeast

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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