Root & Tuber · Traditional Chinese Medicine

Rehmannia Glutinosa (Shu Di Huang)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Rehmannia glutinosa is a Traditional Chinese Medicine root containing catalpol and rehmannioside compounds that support kidney function and blood circulation. The herb's steamed form (Shu Di Huang) tonifies kidney yin energy and may enhance adrenal health through hypothalamic-pituitary-adrenal axis modulation.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryRoot & Tuber

GroupTraditional Chinese Medicine

Public Score StatusProvisional Moderate

Primary Keywordrehmannia glutinosa benefits

Rehmannia Glutinosa close-up macro showing natural texture and detail — rich in anti-inflammatory, antioxidant, hematopoietic

Rehmannia Glutinosa (Shu Di Huang) — botanical close-up

Reported Benefits (Provisional)

Supports kidney and adrenal health by nourishing these organs and enhancing their function. This can improve stress response and energy levels. - Promotes blood circulation and may alleviate anemia by increasing red blood cell production. This enhances oxygen delivery throughout the body, boosting vitality. - Exhibits anti-inflammatory properties by inhibiting pro-inflammatory cytokines, which can reduce pain and swelling in chronic conditions. This supports joint health and mobility. - Enhances immune function by stimulating the production of white blood cells, improving the body's ability to fight infections. - Supports liver health by aiding in detoxification processes, which can improve metabolic health and reduce toxin buildup. - Improves bone health by providing essential minerals like calcium and phosphorus, crucial for maintaining bone density. - Supports hormonal balance by modulating endocrine function, which can improve reproductive health and alleviate symptoms of hormonal imbalances.

Origin & History

Natural habitat

Rehmannia Glutinosa, also known as Shu Di Huang, is a root native to China. It is traditionally steamed and dried to enhance its therapeutic properties, often used in herbal decoctions.

“Rehmannia has been a staple in Traditional Chinese Medicine for centuries, often used in formulations to nourish the blood and support kidney function.”Traditional Medicine

Research Narrative (Provisional)

Animal studies support rehmannia's anti-inflammatory and immune-boosting effects. Limited human trials suggest potential benefits in kidney health and anemia management.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in iridoid glycosides and polysaccharides. - Contains vitamins A and C. - Provides essential minerals like calcium and magnesium.

Reported Mechanism (Provisional)

Mechanism of Action

Rehmannia glutinosa's primary bioactive compound catalpol activates the PI3K/Akt signaling pathway, promoting cellular survival and reducing oxidative stress in kidney tissues. The herb's rehmannioside compounds enhance erythropoiesis by stimulating EPO production, while iridoid glycosides modulate the HPA axis to support adrenal function. Additional compounds like acteoside provide nephroprotective effects through anti-inflammatory mechanisms.

Clinical Narrative (Provisional)

Limited human studies exist for rehmannia glutinosa as a standalone ingredient, with most research conducted in animal models or as part of Traditional Chinese Medicine formulas. Preclinical studies in rats demonstrate nephroprotective effects at doses of 200-400mg/kg, showing improved kidney function markers and reduced oxidative damage. One small human trial (n=60) of a rehmannia-containing formula showed modest improvements in chronic kidney disease markers over 12 weeks. The evidence base remains preliminary and requires larger, well-controlled human trials to establish clinical efficacy.

Also Known As

Rehmannia glutinosaChinese FoxgloveShu Di HuangPrepared RehmanniaSteamed Rehmannia RootDi HuangChinese RehmanniaGlutinous Rehmannia

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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