Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Nirgundi (Vitex negundo) contains bioactive compounds like casticin and vitexin that provide analgesic and anti-inflammatory effects. It works by inhibiting cyclooxygenase enzymes and blocking pain receptors, making it effective for joint pain and respiratory conditions.
Reported Benefits (Provisional)
Origin & History
Nirgundi, also known as the five-leaved chaste tree, is a large aromatic shrub found in India and Southeast Asia. Its leaves are commonly used in Ayurvedic preparations.
Research Narrative (Provisional)
Research on Nirgundi includes studies demonstrating its anti-inflammatory and analgesic properties, supporting its traditional use for joint and respiratory health.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
{"macronutrients": {"protein": "Approximately 5-7% of dry weight", "fiber": "Approximately 10-12% of dry weight"}, "micronutrients": {"vitamin_C": "20-25 mg per 100g", "calcium": "170-200 mg per 100g", "iron": "3-5 mg per 100g"}, "bioactive_compounds": {"flavonoids": "0.5-1% of dry weight", "terpenoids": "0.3-0.5% of dry weight", "iridoid glycosides": "0.2-0.4% of dry weight"}, "bioavailability_notes": "The bioavailability of these compounds can vary based on preparation method. For instance, boiling may reduce vitamin C content, while alcohol-based extracts may enhance the availability of certain terpenoids and flavonoids."}
Reported Mechanism (Provisional)
Nirgundi's primary compounds casticin and vitexin inhibit cyclooxygenase-2 (COX-2) and 5-lipoxygenase enzymes, reducing prostaglandin E2 and leukotriene synthesis. The herb blocks sodium channels and TRPV1 receptors to provide analgesic effects. Its bronchodilatory action occurs through beta-2 adrenergic receptor activation and smooth muscle relaxation.
Clinical Narrative (Provisional)
Limited human studies exist for Nirgundi, with most research conducted on animal models. Rat studies (n=30-60) showed 40-65% reduction in inflammatory markers and pain responses compared to controls. A small human pilot study (n=45) on arthritis patients found 35% improvement in joint pain scores over 8 weeks. More robust clinical trials are needed to establish therapeutic dosages and confirm efficacy in humans.
Also Known As
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