Vitamin & Mineral · Mineral

Manganese Bisglycinate

Provisional Moderate Scorevitamin

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Manganese bisglycinate is a chelated form of manganese bound to two glycine amino acids for enhanced absorption. It functions as a cofactor for superoxide dismutase and enzymes involved in bone matrix formation and glucose metabolism.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryVitamin & Mineral

GroupMineral

Public Score StatusProvisional Moderate

Primary Keywordmanganese bisglycinate benefits

Manganese Bisglycinate close-up macro showing natural texture and detail — rich in cofactor, antioxidant, bone health

Manganese Bisglycinate — botanical close-up

Reported Benefits (Provisional)

Supports bone health by aiding in the formation of connective tissue, crucial for maintaining strong bones and joints. It enhances calcium absorption. - Acts as an antioxidant, protecting cells from free radical damage, which can slow down the aging process. - Supports carbohydrate metabolism, helping to regulate blood sugar levels and prevent spikes. - Enhances wound healing by promoting collagen formation, essential for skin repair and regeneration. - Supports brain health by participating in neurotransmitter synthesis, which can improve cognitive function and mood. - May reduce the risk of osteoporosis by improving bone mineral density, particularly in postmenopausal women. - Supports reproductive health by influencing hormone synthesis, crucial for fertility and sexual health.

Origin & History

Natural habitat

Manganese bisglycinate is a chelated form of manganese, where manganese is bound to the amino acid glycine. This form is synthesized to enhance the bioavailability and absorption of manganese, making it an effective supplement for supporting bone and connective tissue health.

“Manganese has been recognized for its role in bone health since the 20th century. The chelated form, bisglycinate, was developed to improve absorption and reduce side effects.”Traditional Medicine

Research Narrative (Provisional)

Emerging research, including some human trials, suggests manganese bisglycinate's role in supporting bone health and antioxidant protection. More studies are needed to confirm its cognitive benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Provides manganese, an essential trace mineral for enzyme function. - Highly bioavailable form, ensuring effective absorption. - Contains glycine, which aids in reducing gastrointestinal side effects.

Reported Mechanism (Provisional)

Mechanism of Action

Manganese bisglycinate releases manganese ions that activate manganese superoxide dismutase (MnSOD) in mitochondria, neutralizing superoxide radicals. The mineral serves as a cofactor for glycosyltransferases in cartilage synthesis and pyruvate carboxylase in gluconeogenesis. The glycine chelation protects manganese from binding with fiber and phytates, improving intestinal absorption through amino acid transporters.

Clinical Narrative (Provisional)

Limited clinical trials exist specifically for manganese bisglycinate, though studies on manganese supplementation show modest benefits. A 12-week study of 334 postmenopausal women found 5mg daily manganese (with other minerals) improved bone mineral density by 1.5%. Absorption studies indicate chelated forms like bisglycinate achieve 3-5 times higher bioavailability than manganese sulfate. Most evidence comes from observational studies linking adequate manganese intake to reduced osteoporosis risk.

Also Known As

Manganese diglycinateMn-bisglycinateChelated manganeseManganese glycinate chelateBis(glycinato)manganeseManganese amino acid chelate

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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