Mushroom · Mushroom/Fungi

Lentinula edodes

Provisional Strong Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Lentinula edodes (shiitake mushroom) contains beta-glucan polysaccharides that enhance immune function by activating natural killer cells and macrophages. The bioactive compound eritadenine inhibits HMG-CoA reductase, lowering cholesterol levels and supporting cardiovascular health.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryMushroom

GroupMushroom/Fungi

Public Score StatusProvisional Strong

Primary KeywordLentinula edodes benefits

Lentinula edodes — botanical close-up

Reported Benefits (Provisional)

Lentinula edodes, or shiitake, supports immune health with its polysaccharides, enhancing natural killer cell activity. These compounds also help in combating infections. - It contains eritadenine, which may lower cholesterol by inhibiting cholesterol absorption. This supports cardiovascular health. - The mushroom's antioxidants protect against oxidative stress, promoting cellular longevity. They also contribute to skin health by reducing signs of aging. - Its vitamin D content supports bone health by enhancing calcium absorption. Vitamin D also plays a role in immune regulation. - Lentinula edodes' beta-glucans improve gut health by acting as prebiotics. They nourish beneficial gut bacteria, enhancing digestive function. - The mushroom may reduce blood pressure by promoting vasodilation. This effect supports overall heart health. - Its anti-inflammatory properties help in reducing inflammation, benefiting those with chronic inflammatory conditions.

Origin & History

Natural habitat

Lentinula edodes, commonly known as shiitake, is an edible mushroom native to East Asia. It is widely cultivated for its culinary and medicinal uses.

“Shiitake has been used in traditional Chinese medicine for centuries and is a staple in Asian cuisine, valued for its umami flavor.”Traditional Medicine

Research Narrative (Provisional)

Studies highlight shiitake's potential cholesterol-lowering and immune-supporting properties, though further research is needed to fully understand its health benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in B vitamins. - Contains polysaccharides and eritadenine. - Provides dietary fiber. - Low in calories and fat.

Reported Mechanism (Provisional)

Mechanism of Action

Beta-glucan polysaccharides in Lentinula edodes bind to complement receptor 3 (CR3) on immune cells, triggering cytokine production and enhancing natural killer cell activity. Eritadenine inhibits HMG-CoA reductase and blocks cholesterol absorption in the intestines. Additional compounds like lentinan activate toll-like receptors, further stimulating immune responses.

Clinical Narrative (Provisional)

Human studies with 50-100 participants show shiitake extract (3-6g daily) can reduce total cholesterol by 7-12% within 4-8 weeks. Randomized controlled trials demonstrate enhanced immune markers including increased NK cell activity and cytokine production. Most research focuses on extracted polysaccharides rather than whole mushroom consumption. Evidence is moderate quality with small sample sizes limiting definitive conclusions.

Also Known As

Lentinula edodesShiitakeShiitake mushroomJapanese forest mushroomBlack forest mushroomXiang guDonkoShiang-ku

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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