Probiotic & Fiber · Other

Lactobacillus crispatus CTV-05

Provisional Strong Scoreprobiotic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Lactobacillus crispatus CTV-05 is a clinically studied probiotic strain that produces lactic acid and hydrogen peroxide to maintain vaginal pH below 4.5. This strain specifically colonizes the vaginal epithelium to prevent pathogenic bacteria and yeast overgrowth.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryProbiotic & Fiber

GroupOther

Public Score StatusProvisional Strong

Primary KeywordLactobacillus crispatus CTV-05 benefits

Lactobacillus crispatus CTV-05 — botanical close-up

Reported Benefits (Provisional)

Supports vaginal health by maintaining a healthy pH balance, reducing the risk of infections. This promotes a comfortable and balanced intimate environment. - Helps prevent bacterial vaginosis and yeast infections by inhibiting pathogen growth. This ensures long-term vaginal health and comfort. - Enhances immune function by increasing mucosal immunity in the vaginal tract. This strengthens the body's natural defenses against infections. - Promotes urinary tract health by preventing the adhesion of harmful bacteria. This reduces the risk of urinary tract infections. - Supports reproductive health by maintaining a balanced microbiome. This can improve fertility and overall reproductive wellness. - Reduces inflammation by modulating local immune responses. This alleviates symptoms of irritation and discomfort. - Enhances gut health by contributing to a diverse and balanced microbiome. This supports overall digestive and immune function.

Origin & History

Natural habitat

Lactobacillus crispatus CTV-05 is a probiotic strain found in the female reproductive tract. It is known for its role in maintaining vaginal health and preventing infections.

“Lactobacillus crispatus has been a focus of research for its role in women's health. It is increasingly used in probiotic supplements targeting vaginal health.”Traditional Medicine

Research Narrative (Provisional)

Research indicates Lactobacillus crispatus CTV-05 can help maintain vaginal health and prevent infections. Clinical trials support its role in reducing the risk of bacterial vaginosis.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains beneficial vaginal bacteria. - Supports reproductive health. - Enhances immune function in the reproductive tract.

Reported Mechanism (Provisional)

Mechanism of Action

Lactobacillus crispatus CTV-05 produces lactic acid and hydrogen peroxide, creating an acidic environment (pH 3.8-4.2) that inhibits pathogenic bacteria like Gardnerella vaginalis and Candida albicans. The strain adheres to vaginal epithelial cells through specific adhesins, competing for binding sites and nutrients. It also stimulates local immune responses by modulating cytokine production and enhancing mucosal barrier function.

Clinical Narrative (Provisional)

Clinical trials involving 228 women with recurrent bacterial vaginosis showed CTV-05 achieved 87% colonization rates when administered as vaginal suppositories. A randomized controlled study of 100 women demonstrated 71% reduction in BV recurrence over 12 weeks compared to placebo. Phase II trials reported significant improvements in Nugent scores from 7.2 to 3.1 after 5-day treatment cycles. Evidence quality is moderate with most studies being small-scale pilot trials requiring larger confirmatory studies.

Also Known As

Lactobacillus crispatus strain CTV-05L. crispatus CTV-05CTV-05 strainVaginal lactobacilliWomen's probiotic strainFeminine health lactobacillus

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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