Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: CLAIM_LEVEL_HUMAN_REVIEW_REQUIRED
Human sleep evidence for L-ornithine is limited to a small trial in mildly stressed healthy workers. The result is promising but does not establish effectiveness across populations or at trace doses.
Origin & History
L-Ornithine is an amino acid produced in the urea cycle, primarily in the liver. It is found in meat, fish, and dairy products, and can be synthesized in laboratories for supplementation.
Research Narrative (Provisional)
A randomized controlled trial enrolled 52 mildly stressed healthy workers and evaluated 400 mg/day of L-ornithine (PMID 24889392). The narrow population and single-study evidence limit generalization.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Non-proteinogenic amino acid. - Key role in the urea cycle. - Found in protein-rich foods.
Reported Mechanism (Provisional)
L-Ornithine functions as a substrate in the hepatic urea cycle, where it combines with carbamoyl phosphate via ornithine transcarbamylase to form citrulline, facilitating ammonia elimination. It also stimulates growth hormone release through interaction with the hypothalamic-pituitary axis and reduces cortisol levels by modulating the hypothalamic-pituitary-adrenal axis. Additionally, L-Ornithine can be converted to putrescine via ornithine decarboxylase, supporting cellular regeneration processes.
Clinical Narrative (Provisional)
Evidence grade: limited. One small trial cannot establish a broadly effective sleep dose.
Also Known As
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