Japanese Kampo Medicine · Traditional Chinese Medicine

Keishibukuryogan (Cinnamon and Poria)

Provisional Moderate Scorebotanical

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Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Keishibukuryogan is a traditional Kampo formula combining cinnamon bark, poria mushroom, and three other herbs that improves blood circulation through vasodilation mechanisms. The formula's bioactive compounds including cinnamaldehyde and beta-glucans work synergistically to support cardiovascular health and metabolic function.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryJapanese Kampo Medicine

GroupTraditional Chinese Medicine

Public Score StatusProvisional Moderate

Primary KeywordKeishibukuryogan benefits

Keishibukuryogan close-up macro showing natural texture and detail — rich in anti-inflammatory, antioxidant, circulatory enhancer

Keishibukuryogan (Cinnamon and Poria) — botanical close-up

Reported Benefits (Provisional)

Promotes cardiovascular health by reducing blood pressure, as evidenced by a 15% decrease in hypertensive patients. - Enhances metabolism through thermogenic properties, aiding in weight management. - Supports digestive health by balancing gut microbiota, which improves nutrient absorption. - Reduces inflammation by inhibiting cytokine production, providing relief from chronic pain. - Boosts cognitive function by enhancing neuroplasticity, which can improve learning and memory. - Strengthens the immune system by increasing natural killer cell activity, helping to prevent illnesses. - Improves skin health by reducing oxidative stress, leading to a clearer complexion.

Origin & History

Natural habitat

Keishibukuryogan is a Kampo formula combining Cinnamon and Poria, traditionally used in Japanese medicine. It is prepared from natural plant ingredients.

“This formula has been used in traditional Japanese medicine for centuries, often prescribed for women's health and circulatory issues.”Traditional Medicine

Research Narrative (Provisional)

Research, including some clinical trials, suggests Keishibukuryogan may help with circulation and menopausal symptoms, but further studies are needed for confirmation.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

{"macronutrients": {"fiber": "3.5g per 100g", "protein": "2.1g per 100g"}, "micronutrients": {"vitamin_c": "5mg per 100g", "calcium": "120mg per 100g", "iron": "1.8mg per 100g"}, "bioactive_compounds": {"cinnamaldehyde": "0.8mg per 100g", "polysaccharides": "4g per 100g", "triterpenoids": "0.5mg per 100g"}, "bioavailability_notes": "The bioavailability of triterpenoids and polysaccharides can be enhanced through proper preparation methods such as decoction. Vitamin C and calcium are moderately bioavailable, with absorption influenced by the presence of other dietary components."}

Reported Mechanism (Provisional)

Mechanism of Action

Keishibukuryogan works through multiple pathways, with cinnamaldehyde from cinnamon bark activating TRPA1 channels to promote vasodilation and improve blood flow. The poria-derived beta-glucans modulate immune responses and support gut microbiota balance through toll-like receptor interactions. These compounds collectively enhance nitric oxide production and reduce inflammatory cytokines, supporting cardiovascular and metabolic health.

Clinical Narrative (Provisional)

Limited clinical studies show promising cardiovascular effects, with one study reporting 15% blood pressure reduction in hypertensive patients. Most research consists of small-scale trials and traditional use documentation rather than large randomized controlled trials. Evidence suggests metabolic benefits including thermogenic effects and digestive support, though more robust clinical data is needed. The formula's safety profile appears favorable based on traditional use patterns, but modern clinical validation remains incomplete.

Also Known As

Cinnamomum cassia + Poria cocosKeishi-bukuryo-ganGui Zhi Fu Ling WanCinnamon-Poria FormulaKBGKeishibukuryō-ganCassia Twig and Poria Pill

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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