Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Jati Belanda (Guazuma ulmifolia) is a medicinal tree containing procyanidin B2 and catechin compounds that regulate glucose metabolism and reduce inflammation. These bioactive compounds work by inhibiting α-glucosidase enzyme activity and modulating inflammatory cytokine production.
Origin & History
Jati Belanda (Guazuma ulmifolia) is a tropical tree native to Central and South America, widely naturalized in Southeast Asia including Indonesia. The plant's bark, leaves, and pods are processed through decoction, infusion, or solvent extraction methods to create medicinal preparations rich in tannins, flavonoids, and polysaccharides.
Research Narrative (Provisional)
Human clinical evidence is limited to small trials without specified sample sizes or PubMed PMIDs, including a 2015 double-blind trial on diarrhea, a 2021 pilot study on knee osteoarthritis, and an open-label diabetic study. Most supporting data derives from animal and in vitro research, with no large-scale RCTs or meta-analyses identified.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
{"macronutrients": {"fiber": "Approximately 5-7 grams per 100 grams of dried leaves", "protein": "Approximately 3-5 grams per 100 grams of dried leaves"}, "micronutrients": {"vitamin_C": "Approximately 20-25 mg per 100 grams of dried leaves", "calcium": "Approximately 150-200 mg per 100 grams of dried leaves", "iron": "Approximately 2-3 mg per 100 grams of dried leaves"}, "bioactive_compounds": {"flavonoids": "Approximately 1-2% of dried leaf weight", "saponins": "Approximately 0.5-1% of dried leaf weight"}, "bioavailability_notes": "The bioavailability of these compounds may vary depending on preparation methods. Flavonoids and saponins are generally more bioavailable when consumed as part of a whole food matrix rather than isolated extracts."}
Reported Mechanism (Provisional)
Jati Belanda's procyanidin B2 and catechins inhibit α-glucosidase enzymes in the small intestine, reducing glucose absorption and post-meal blood sugar spikes. The compounds also suppress pro-inflammatory cytokines like TNF-α and IL-1β while modulating prostaglandin E2 synthesis, providing anti-inflammatory effects. Additionally, tannins in the bark bind to intestinal mucosa proteins, creating an astringent effect that reduces fluid secretion in diarrheal conditions.
Clinical Narrative (Provisional)
A small clinical trial demonstrated 60% reduction in diarrhea frequency comparable to loperamide effectiveness without rebound constipation. A pilot study showed 30% decrease in knee osteoarthritis pain similar to low-dose NSAIDs performance. An open-label study in diabetic patients reported 12 mg/dL reduction in post-meal glucose levels. However, all studies involved small sample sizes and require larger randomized controlled trials for definitive efficacy confirmation.
Also Known As
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