Root & Tuber · Traditional Chinese Medicine

He Shou Wu (Fo-Ti / Polygonum Multiflorum)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

He Shou Wu (Polygonum multiflorum) is a traditional Chinese herb containing stilbene glycosides that support hair health and longevity. Its active compounds work through antioxidant pathways and by modulating melanin synthesis in hair follicles.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryRoot & Tuber

GroupTraditional Chinese Medicine

Public Score StatusProvisional Moderate

Primary KeywordHe Shou Wu benefits

He Shou Wu close-up macro showing natural texture and detail — rich in antioxidant, hepatoprotective, immunomodulatory

He Shou Wu (Fo-Ti / Polygonum Multiflorum) — botanical close-up

Reported Benefits (Provisional)

Supports hair health by nourishing hair follicles and may prevent premature graying. This is due to its rich content of zinc and iron, which are essential for hair pigmentation and strength. - Promotes longevity and vitality by acting as an adaptogen, enhancing the body's resilience to stress. This can lead to improved energy levels and overall well-being. - Enhances cognitive function by increasing blood flow to the brain and reducing oxidative stress. This supports memory retention and mental clarity. - Supports liver health by detoxifying and regenerating liver cells, improving metabolic processes. This can aid in the management of liver-related disorders. - Boosts immune function by enhancing white blood cell activity, which helps in fighting infections. This strengthens the body's natural defense mechanisms. - Improves cardiovascular health by lowering cholesterol levels and improving circulation. This reduces the risk of heart disease and promotes heart health. - Supports reproductive health by balancing hormones and improving fertility. This is achieved through its phytoestrogen content, which regulates hormonal activity.

Origin & History

Natural habitat

He Shou Wu, or Fo-Ti, is a root from the Polygonum Multiflorum plant, native to China. It is traditionally harvested, sliced, and processed with black beans to enhance its medicinal properties.

“He Shou Wu has been used in Traditional Chinese Medicine for centuries, often associated with longevity and youthfulness. It is named after a legend of a man who regained his vitality and black hair by consuming the root.”Traditional Medicine

Research Narrative (Provisional)

Animal studies suggest He Shou Wu's potential in promoting hair growth and liver health. Human trials are limited but indicate possible cognitive and anti-aging benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains stilbenes and anthraquinones. - Rich in zinc and iron. - Provides lecithin and other beneficial lipids.

Reported Mechanism (Provisional)

Mechanism of Action

He Shou Wu's primary bioactive compounds, including 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) and emodin, activate antioxidant pathways through Nrf2 signaling. These stilbenes enhance tyrosinase activity, promoting melanin synthesis in hair follicles, while also supporting mitochondrial function and reducing oxidative stress markers.

Clinical Narrative (Provisional)

Limited human studies exist for He Shou Wu, with most evidence from animal models and traditional use. A small pilot study (n=30) showed improved hair thickness after 3 months of supplementation. Animal studies demonstrate hepatoprotective effects and improved antioxidant status, but larger randomized controlled trials in humans are needed to confirm therapeutic benefits.

Also Known As

Polygonum multiflorumFo-TiChinese KnotweedFleeceflower RootRed-kneed KnotweedClimbing KnotweedShou Wu

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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