Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Hangeshashinto is a traditional Japanese Kampo formula containing Pinellia ternata that reduces gastrointestinal inflammation through inhibition of TNF-α and IL-1β cytokines. This herbal combination specifically targets oral mucositis and gastric irritation by modulating inflammatory cascades in mucosal tissues.
Reported Benefits (Provisional)
Origin & History
Hangeshashinto is a Kampo formula composed of herbs such as pinellia tuber, scutellaria root, and glycyrrhiza. It is traditionally used to address oral and gastrointestinal inflammation and is produced through meticulous blending of its components.
Research Narrative (Provisional)
Clinical studies, including RCTs, have indicated that Hangeshashinto may be effective in reducing chemotherapy-induced oral mucositis. Its anti-inflammatory properties are supported by several meta-analyses.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Hangeshashinto is a Kampo (Japanese traditional) formula comprising 7 herbs: Pinellia ternata (banxia, 5g), Scutellaria baicalensis (huangqin, 2.5g), Zingiber officinale dried rhizome (ganjiang, 2.5g), Panax ginseng (renshen, 2.5g), Glycyrrhiza uralensis (gancao, 2.5g), Coptis chinensis (huanglian, 1g), and Ziziphus jujuba (dazao, 2.5g). Key bioactive compounds include baicalin and baicalein (flavonoids from Scutellaria, ~30-50 mg per standard dose), berberine (isoquinoline alkaloid from Coptis, ~15-25 mg per dose), ginsenosides Rb1 and Rg1 (triterpenoid saponins from ginseng, ~5-10 mg per dose), glycyrrhizin (triterpene saponin from licorice, ~20-40 mg per dose), 6-gingerol and 6-shogaol (phenolic compounds from ginger, ~3-8 mg per dose), and homogentisic acid and ephedrine-related alkaloids from Pinellia tuber. The formula is essentially devoid of macronutrients (negligible protein, fat, carbohydrate, and fiber per decoction dose). Mineral content is trace-level, including small amounts of potassium, calcium, and magnesium leached during decoction. Bioavailability of berberine is inherently low (~5% oral absorption) but is enhanced in this formula by glycyrrhizin's membrane permeability effects; baicalin undergoes hydrolysis to baicalein by gut microbiota, increasing intestinal absorption significantly.
Reported Mechanism (Provisional)
Hangeshashinto's active compounds, including ephedrine from Pinellia and ginsenosides, suppress pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 through NF-κB pathway inhibition. The formula enhances mucosal barrier function by upregulating tight junction proteins claudin-1 and occludin. Additionally, it stimulates prostaglandin E2 production, which promotes gastric mucus secretion and epithelial cell regeneration.
Clinical Narrative (Provisional)
A randomized controlled trial with 80 chemotherapy patients demonstrated 40% reduction in oral mucositis severity scores compared to placebo. Japanese observational studies involving 156 participants showed significant improvements in gastric discomfort within 2 weeks. Most clinical evidence comes from small-scale trials and traditional use studies, with limited large-scale Western research. The formula shows consistent benefits for mucosal inflammation across multiple Japanese clinical investigations.
Also Known As
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