Mushroom · Mushroom/Fungi

Agaricus blazei ethanol extract

Provisional Strong Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Agaricus blazei ethanol extract contains beta-glucans and other polysaccharides that stimulate immune cell activity through Toll-like receptor activation. This medicinal mushroom extract primarily enhances natural killer cell function and macrophage activity to support immune defense.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryMushroom

GroupMushroom/Fungi

Public Score StatusProvisional Strong

Primary KeywordAgaricus blazei ethanol extract benefits

Agaricus blazei ethanol extract — botanical close-up

Reported Benefits (Provisional)

Supports immune function by enhancing natural killer cell activity, crucial for combating viruses and tumors. Research indicates a 35% increase in NK cell activity. - Provides anti-cancer properties by inducing apoptosis in malignant cells, offering a natural adjunct to cancer therapies. - Reduces inflammation by modulating immune responses, essential for chronic disease prevention. - Acts as a powerful antioxidant, protecting against oxidative stress and cellular damage. - Supports cardiovascular health by lowering blood pressure and cholesterol levels, reducing heart disease risk. - Enhances energy levels by improving mitochondrial efficiency, leading to increased endurance. - May support weight management by regulating metabolism and reducing fat accumulation.

Origin & History

Agaricus blazei ethanol extract — origin

Natural habitat

Agaricus blazei, also known as the Almond Mushroom, is native to Brazil and is known for its medicinal properties.

“The Almond Mushroom has been used in traditional medicine in Brazil for centuries, often valued for its immune-boosting properties.”Traditional Medicine

Research Narrative (Provisional)

Studies suggest that Agaricus blazei may enhance immune function and has potential anti-cancer effects. Further research is needed to confirm these benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- High in beta-glucans and polysaccharides. - Contains vitamins B and D. - Low in calories and carbohydrates.

Reported Mechanism (Provisional)

Mechanism of Action

The beta-glucans in Agaricus blazei ethanol extract bind to Toll-like receptors (TLR-2 and TLR-4) on immune cells, triggering cytokine release including IL-1β, TNF-α, and interferon-γ. This cascade activates natural killer cells, macrophages, and dendritic cells through the NF-κB signaling pathway. The extract's ergosterol and protein-bound polysaccharides further enhance immune surveillance mechanisms.

Clinical Narrative (Provisional)

Human studies show Agaricus blazei extract increases natural killer cell activity by 35% in healthy adults taking 300-500mg daily for 4-8 weeks. A randomized controlled trial with 78 participants demonstrated enhanced immune markers and reduced infection rates. Cancer-related studies are primarily in vitro and animal models, with limited human clinical data. Most research involves small sample sizes of 20-100 participants with short-term follow-up periods.

Also Known As

Agaricus subrufescensAlmond MushroomBrazilian MushroomHimematsutakeCogumelo do SolRoyal Sun AgaricusABMCogumelo de Deus

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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