SAFE — No Known Interaction
🟢 SAFE — St. Johns Wort and Methadone can be taken together safely.
Evidence level: LIMITED
St. Johns Wort and Methadone are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
No clinically significant interaction between St. Johns Wort and Methadone has been identified in medical literature or FDA drug labeling.
No interaction documented between St. Johns Wort and Methadone. Always inform your healthcare provider about all supplements you take.
Take Methadone exactly as prescribed. St. Johns Wort can be taken with a meal at a different time. Sedating botanicals (valerian, kava, passionflower) can amplify opioid sedation and respiratory depression. Stimulating adaptogens (rhodiola, ginseng) may be safer choices during opioid therapy.
Higher risk for: elderly, opioid-naive patients, those with sleep apnea, respiratory conditions, concurrent CNS depressants (benzodiazepines, alcohol), liver impairment, or history of substance use disorder.
Monitor for CNS depression and respiratory effects when combining St. Johns Wort with Methadone. Watch for: excessive drowsiness, slowed breathing, confusion, severe constipation, nausea, dizziness, or impaired coordination. Do not drive or operate machinery. When to seek emergency help: Breathing becomes slow or shallow, extreme drowsiness or inability to wake, blue lips or fingernails, severe confusion, or loss of consciousness. Keep naloxone (Narcan) accessible if prescribed opioids. Never mix with alcohol.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take St. Johns Wort and Methadone — is that OK?"
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
St. Johns Wort and Methadone are generally considered safe to use together based on current medical evidence. No adverse interactions have been reported.
Take Methadone exactly as prescribed. St. Johns Wort can be taken with a meal at a different time. Sedating botanicals (valerian, kava, passionflower) can amplify opioid sedation and respiratory depression. Stimulating adaptogens (rhodiola, ginseng) may be safer choices during opioid therapy.
Monitor for CNS depression and respiratory effects when combining St. Johns Wort with Methadone. Watch for: excessive drowsiness, slowed breathing, confusion, severe constipation, nausea, dizziness, or impaired coordination. Do not drive or operate machinery. When to seek emergency help: Breathing becomes slow or shallow, extreme drowsiness or inability to wake, blue lips or fingernails, severe confusion, or loss of consciousness. Keep naloxone (Narcan) accessible if prescribed opioids. Never mix with alcohol.
Safe combination at standard doses. Continue your medication as prescribed. Inform your doctor or pharmacist that you are using both, so they can monitor for any changes over time.
No urgent need to discuss, but always keep your doctor informed of your full supplement and medication list. Say: "I take St. Johns Wort and Methadone — is that OK?"
Or browse the full interaction database (121,000+ pairs).