STOP — Contraindicated
FDA contraindication. Same linezolid-serotonergic drug interaction as with SSRIs. Use only if infection is life-threatening with no alternative antibiotic.
Evidence level: STRONG
Linezolid (an antibiotic that acts as an MAO inhibitor) combined with Cymbalta (duloxetine) can cause severe serotonin syndrome. The FDA specifically contraindicates this combination.
Linezolid is a reversible non-selective MAO inhibitor. Duloxetine is an SNRI (serotonin and norepinephrine reuptake inhibitor). FDA linezolid label contraindicates concurrent serotonergic drugs.
If you take Cymbalta and develop a serious infection, tell the hospital staff. Linezolid should be avoided — alternative antibiotics exist for most infections.
Follow each medication's specific timing instructions. Linezolid — check if it requires an empty stomach or should be taken with food. Duloxetine follows its normal schedule. Complete the full antibiotic course as prescribed.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
High fever, agitation, muscle rigidity, rapid heartbeat, blood pressure swings, confusion, seizures
Use alternative antibiotics (vancomycin, daptomycin). If linezolid is essential, discontinue duloxetine and monitor for serotonin syndrome.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Linezolid (an antibiotic that acts as an MAO inhibitor) combined with Cymbalta (duloxetine) can cause severe serotonin syndrome. The FDA specifically contraindicates this combination.
Follow each medication's specific timing instructions. Linezolid — check if it requires an empty stomach or should be taken with food. Duloxetine follows its normal schedule. Complete the full antibiotic course as prescribed.
High fever, agitation, muscle rigidity, rapid heartbeat, blood pressure swings, confusion, seizures
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Use alternative antibiotics (vancomycin, daptomycin). If linezolid is essential, discontinue duloxetine and monitor for serotonin syndrome.
Or browse the full interaction database (121,000+ pairs).