MAJOR — Use With Caution
FDA-documented CYP1A2 interaction. Monitor for increased olanzapine effects. Consider dose reduction or alternative antibiotic.
Evidence level: STRONG
Ciprofloxacin can increase olanzapine (Zyprexa) levels by blocking the enzyme that breaks it down, causing increased sedation, dizziness, and metabolic side effects.
Ciprofloxacin inhibits CYP1A2. Olanzapine is metabolized by CYP1A2. Increased olanzapine levels with sedation and metabolic effects. FDA olanzapine label acknowledges CYP1A2 interactions.
Tell your doctor you take Zyprexa before starting ciprofloxacin. Watch for increased drowsiness or dizziness. Alternative antibiotics may be safer.
Follow each medication's specific timing instructions. Ciprofloxacin — check if it requires an empty stomach or should be taken with food. Olanzapine follows its normal schedule. Complete the full antibiotic course as prescribed.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Excessive drowsiness, dizziness, low blood pressure when standing, weight gain, high blood sugar
Consider alternative antibiotics. If ciprofloxacin is necessary, monitor for increased olanzapine effects and consider temporary dose reduction.
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Ciprofloxacin can increase olanzapine (Zyprexa) levels by blocking the enzyme that breaks it down, causing increased sedation, dizziness, and metabolic side effects.
Follow each medication's specific timing instructions. Ciprofloxacin — check if it requires an empty stomach or should be taken with food. Olanzapine follows its normal schedule. Complete the full antibiotic course as prescribed.
Excessive drowsiness, dizziness, low blood pressure when standing, weight gain, high blood sugar
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Consider alternative antibiotics. If ciprofloxacin is necessary, monitor for increased olanzapine effects and consider temporary dose reduction.
Or browse the full interaction database (121,000+ pairs).