Leaf & Herb · Other

Vitex (Chaste Tree Berry)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Vitex agnus-castus contains diterpenes that act as dopamine receptor agonists, reducing prolactin secretion from the anterior pituitary gland. This hormonal modulation helps regulate menstrual cycles and reduces premenstrual syndrome symptoms.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryLeaf & Herb

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordvitex benefits

Vitex close-up macro showing natural texture and detail — rich in dopaminergic modulator, prolactin inhibitor, hormonal regulator

Vitex (Chaste Tree Berry) — botanical close-up

Reported Benefits (Provisional)

Supports hormonal balance by modulating prolactin levels, which can alleviate symptoms of PMS. This helps reduce mood swings and irritability. - May reduce breast pain and tenderness by up to 50% through its anti-inflammatory properties. This offers comfort during menstrual cycles. - Enhances fertility by promoting regular ovulation. This increases the chances of conception. - May alleviate symptoms of menopause, such as hot flashes, by balancing estrogen levels. This provides relief from discomfort. - Supports skin health by reducing acne linked to hormonal imbalances. This results in clearer, healthier skin. - May improve mood and reduce anxiety by influencing dopamine levels. This leads to enhanced emotional well-being. - Contains antioxidants that protect against oxidative stress, promoting overall health. This supports longevity and vitality.

Origin & History

Natural habitat

Vitex, also known as Chaste Tree Berry, is derived from the fruit of the Vitex agnus-castus plant native to the Mediterranean and Central Asia. The berries are harvested and processed for their hormone-balancing properties.

“Vitex has been used since ancient times for women's health, particularly in Greece and Rome. It was traditionally believed to promote chastity.”Traditional Medicine

Research Narrative (Provisional)

Several RCTs support the use of Vitex for reducing PMS symptoms and improving menstrual regularity. Meta-analyses indicate its efficacy in hormonal balance.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in flavonoids that support hormonal health. - Contains iridoids with anti-inflammatory effects. - Provides essential oils that support overall well-being.

Reported Mechanism (Provisional)

Mechanism of Action

Vitex diterpenes, particularly rotundifuran and 6β,7β-diacetoxy-13-hydroxy-labd-14-en-11-one, bind to dopamine D2 receptors in the pituitary gland. This dopaminergic activity inhibits prolactin release while supporting luteal phase progesterone production. The herb also modulates FSH and LH secretion through hypothalamic-pituitary feedback mechanisms.

Clinical Narrative (Provisional)

A systematic review of 12 randomized controlled trials involving 1,601 women found vitex significantly reduced PMS symptoms compared to placebo. One double-blind study of 170 women showed 42% reduction in PMS symptom scores after three cycles at 20mg daily. Multiple trials demonstrate consistent benefits for breast tenderness, mood symptoms, and cycle irregularities, though most studies are 3-6 months in duration.

Also Known As

Vitex agnus-castusChaste BerryMonk's PepperAbraham's BalmChasteberryWild PepperHemp TreeAgnus Castus

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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