Extract & Compound · Compound

Spermidine

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Spermidine is a naturally occurring polyamine that activates autophagy, the cellular cleaning process that removes damaged proteins and organelles. It works by inhibiting EP300 acetyltransferase, leading to enhanced cellular renewal and longevity.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordspermidine benefits

Spermidine close-up macro showing natural texture and detail — rich in autophagy enhancer, neuroprotective, anti-aging

Spermidine — botanical close-up

Reported Benefits (Provisional)

Supports cellular renewal and longevity by inducing autophagy, a process that removes damaged cells and promotes cellular health. This can lead to a 30% increase in lifespan as shown in animal studies. - Promotes cardiovascular health by reducing arterial stiffness and lowering blood pressure, which decreases the risk of heart disease. - Enhances cognitive function by reducing oxidative stress and inflammation in the brain, potentially lowering the risk of neurodegenerative diseases. - Boosts immune function by modulating immune cell activity, helping the body fight infections more effectively. - Improves skin health by increasing collagen production, leading to firmer and more youthful skin. - Aids in muscle maintenance by reducing muscle loss during aging, supporting overall physical strength. - Supports metabolic health by improving insulin sensitivity, which can help maintain healthy blood sugar levels.

Origin & History

Natural habitat

Spermidine is a polyamine compound found in various foods, including wheat germ, soybeans, and aged cheese. It is extracted through biochemical processes for use in supplements.

“Research on spermidine has focused on its role in cellular aging and longevity, drawing from studies on dietary sources and health outcomes.”Traditional Medicine

Research Narrative (Provisional)

Spermidine has been studied in both animal and human trials for its role in promoting longevity and autophagy. Its effects on cardiovascular and cognitive health are promising.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Polyamine compound involved in cellular growth. - Found in foods like wheat germ and soybeans. - Integral to cellular maintenance and longevity.

Reported Mechanism (Provisional)

Mechanism of Action

Spermidine inhibits the EP300 acetyltransferase enzyme, which prevents acetylation of autophagy-related proteins like ATG5 and ATG7. This deacetylation activates the autophagy machinery, triggering lysosomal degradation of damaged cellular components. The compound also modulates mTOR signaling and AMPK pathways to enhance cellular stress resistance.

Clinical Narrative (Provisional)

Human studies show spermidine supplementation (1.2mg daily) improved memory performance in 85 older adults with subjective cognitive decline over 12 months. A population study of 829 participants found higher dietary spermidine intake correlated with reduced cardiovascular mortality over 20 years. Animal studies demonstrate 25-30% lifespan extension, but long-term human longevity data remains limited. Most evidence comes from observational studies and short-term interventional trials.

Also Known As

N-(3-aminopropyl)butane-1,4-diamineSPDTriamine1,8-Diamino-4-azaoctaneGerontineNeuridine

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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