Extract & Compound · Compound

Rutin

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Rutin is a flavonoid glycoside that strengthens capillary walls by stabilizing collagen and reducing capillary permeability. This polyphenol compound exhibits potent antioxidant activity through free radical scavenging and anti-inflammatory effects via NF-κB pathway inhibition.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordrutin benefits

Rutin close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, vasoprotective

Rutin — botanical close-up

Reported Benefits (Provisional)

Strengthens blood vessels by enhancing collagen production, improving circulation and reducing the risk of varicose veins. - Exhibits strong antioxidant properties, neutralizing free radicals and reducing oxidative stress by 30%, according to studies. - Reduces inflammation by inhibiting pro-inflammatory cytokines, which can alleviate symptoms of chronic inflammatory diseases. - Supports heart health by lowering blood pressure and improving endothelial function, reducing cardiovascular risks. - Enhances skin health by protecting against UV-induced damage, promoting a youthful complexion. - Improves glucose metabolism, aiding in better blood sugar control and reducing the risk of type 2 diabetes. - Boosts brain health by increasing cerebral blood flow, potentially improving cognitive function and memory.

Origin & History

Natural habitat

Rutin is a bioflavonoid found in citrus fruits, buckwheat, and asparagus. It is extracted using solvent extraction and purification processes to isolate the compound.

“Rutin has been used in traditional medicine for its vascular benefits and is a staple in diets rich in flavonoid-containing foods.”Traditional Medicine

Research Narrative (Provisional)

RCTs and observational studies indicate rutin's role in vascular health and its antioxidant capacity. However, more extensive human trials are needed for conclusive evidence.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- High in flavonoids, particularly rutin. - Contains quercetin, another beneficial flavonoid. - Free from fats and low in calories.

Reported Mechanism (Provisional)

Mechanism of Action

Rutin stabilizes vitamin C and enhances collagen synthesis by inhibiting hyaluronidase and collagenase enzymes. It scavenges hydroxyl and superoxide radicals while chelating metal ions that catalyze oxidative reactions. The compound also suppresses inflammatory mediators by blocking NF-κB transcription factor activation and reducing cytokine production.

Clinical Narrative (Provisional)

Human studies using 500-1000mg daily rutin show 30% reduction in oxidative stress markers and improved capillary resistance. A 12-week randomized trial with 60 participants demonstrated significant improvement in chronic venous insufficiency symptoms. Double-blind studies report enhanced microcirculation and reduced edema in varicose vein patients. However, most clinical evidence comes from small-scale studies requiring larger trials for confirmation.

Also Known As

Quercetin-3-O-rutinosideRutosideVitamin PSophorinBirutanRutozidMyricetin-3-rutinoside

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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