Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Trans-resveratrol is a polyphenolic stilbene compound that activates sirtuin proteins and modulates inflammatory pathways. It provides cardiovascular protection through endothelial function improvement and offers potent antioxidant effects against cellular damage.
Reported Benefits (Provisional)
Origin & History
Resveratrol is a polyphenolic compound found in the skin of red grapes, berries, and peanuts. It is typically extracted through a process involving the fermentation of grape skins or chemical synthesis. The trans- form is the most biologically active and stable isomer.
Research Narrative (Provisional)
Numerous RCTs and meta-analyses have demonstrated resveratrol's efficacy in improving cardiovascular health and reducing inflammation. In vitro studies further support its antioxidant properties.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Contains high levels of polyphenols. - Rich in antioxidants. - Low in calories and fats.
Reported Mechanism (Provisional)
Trans-resveratrol activates SIRT1 (sirtuin 1) proteins, which regulate cellular metabolism, DNA repair, and longevity pathways. It inhibits nuclear factor-kappa B (NF-κB), reducing inflammatory cytokine production, and activates AMP-activated protein kinase (AMPK) to improve glucose metabolism. The compound also modulates nitric oxide synthase activity, enhancing endothelial function and vascular health.
Clinical Narrative (Provisional)
Human studies using 100-500mg daily doses show modest improvements in endothelial function and blood flow markers in cardiovascular patients. A 12-week randomized trial with 119 participants demonstrated improved insulin sensitivity with 150mg trans-resveratrol daily. However, longevity and anti-aging benefits observed in animal studies have not been conclusively replicated in human trials. Most clinical evidence is from small studies with short durations, requiring larger long-term trials for definitive health claims.
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