Oil & Fat · Other

Perilla Oil

Provisional Moderate Scorelipid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Perilla oil is a plant-based omega-3 source containing 50-60% alpha-linolenic acid (ALA) that supports cardiovascular and cognitive health. ALA converts to EPA and DHA in the body, though conversion efficiency is limited to 5-15% in humans.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryOil & Fat

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordperilla oil benefits

Perilla Oil close-up macro showing natural texture and detail — rich in anti-inflammatory, antioxidant, cardioprotective

Perilla Oil — botanical close-up

Reported Benefits (Provisional)

Supports cardiovascular health by lowering LDL cholesterol levels, reducing heart disease risk by 15% according to a 2020 study. This is due to its high alpha-linolenic acid content. - Enhances cognitive function by boosting memory and focus, thanks to its omega-3 fatty acids that improve brain cell communication. - Reduces inflammation by inhibiting pro-inflammatory cytokines, which can help manage chronic conditions like arthritis. - Boosts immune system by increasing white blood cell activity, helping the body fend off infections more effectively. - Promotes skin health by maintaining moisture and elasticity, as its antioxidants combat free radical damage. - Aids in weight management by regulating metabolism, as shown in a study where participants lost 5% body weight over 12 weeks. - Improves digestive health by soothing the gut lining, reducing symptoms of IBS through its anti-inflammatory properties.

Origin & History

Natural habitat

Perilla oil is extracted from the seeds of the Perilla frutescens plant, native to East Asia. It is rich in alpha-linolenic acid (ALA), an omega-3 fatty acid, and is obtained through cold pressing.

“Perilla oil has been used in traditional Asian cuisines and medicine for its health benefits and aromatic flavor.”Traditional Medicine

Research Narrative (Provisional)

Research includes observational studies and some human trials, supporting perilla oil's benefits for heart and skin health. Its conversion to EPA and DHA is also studied.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- High in ALA, a plant-based omega-3 fatty acid. - Contains linoleic acid and oleic acid. - Provides 9 kcal per gram.

Reported Mechanism (Provisional)

Mechanism of Action

Alpha-linolenic acid in perilla oil undergoes enzymatic conversion via delta-6-desaturase and elongase enzymes to produce EPA and DHA. These omega-3 metabolites modulate inflammatory pathways by inhibiting cyclooxygenase-2 (COX-2) and 5-lipoxygenase, while promoting specialized pro-resolving mediators. ALA also activates PPAR-alpha receptors, enhancing fatty acid oxidation and improving lipid metabolism.

Clinical Narrative (Provisional)

A 2020 randomized controlled trial (n=180) showed perilla oil supplementation reduced LDL cholesterol by 15% over 12 weeks. Smaller studies (n=40-60) suggest cognitive benefits, though evidence remains preliminary. Most clinical research uses 1-3g daily dosing. Long-term safety data beyond 6 months is limited, and conversion to active omega-3s varies significantly between individuals.

Also Known As

Perilla frutescensShiso oilChinese basil oilWild sesame oilEgoma oilZi su oilBeefsteak plant oil

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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