
Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Peptan is a brand of hydrolyzed collagen peptides containing bioactive peptides with molecular weights of 2-5 kDa. These peptides stimulate fibroblast activity and collagen synthesis in skin, cartilage, and connective tissues through specific amino acid sequences like Pro-Hyp dipeptides.

Reported Benefits (Provisional)
Origin & History

Peptan collagen peptides are derived from bovine or fish sources and are produced through a process of enzymatic hydrolysis to ensure high bioavailability.
Research Narrative (Provisional)
Numerous studies, including RCTs, have shown Peptan's effectiveness in supporting skin health and joint function, with improvements in skin elasticity and joint mobility.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Peptan (Collagen Peptides) is a hydrolyzed type I and type II collagen derived primarily from bovine hides, porcine skin, or fish scales. Per 10 g serving (typical daily dose): ~9–9.5 g protein (>90% protein on dry weight basis), <0.5 g fat, <0.5 g carbohydrates, ~35–40 kcal. Rich in specific amino acids: Glycine (~22–25%, ~2.2–2.5 g/10 g), Proline (~12–14%, ~1.2–1.4 g/10 g), Hydroxyproline (~11–13%, ~1.1–1.3 g/10 g), Alanine (~8–10%, ~0.8–1.0 g/10 g), Glutamic acid (~10%, ~1.0 g/10 g), and Arginine (~8%, ~0.8 g/10 g). Notably low or absent in Tryptophan (<0.1%), making it an incomplete protein. Contains trace minerals depending on source: Calcium (~20–50 mg/10 g from fish-derived), Phosphorus (~10–30 mg/10 g), Sodium (~50–200 mg/10 g depending on processing), and trace amounts of Magnesium and Potassium. No significant vitamin content. Bioactive compounds include specific collagen-derived dipeptides and tripeptides, notably Prolyl-Hydroxyproline (Pro-Hyp) and Hydroxyprolyl-Glycine (Hyp-Gly), which act as signaling molecules for fibroblast and chondrocyte activity. Average molecular weight of peptides: 2,000–5,000 Daltons (optimized for intestinal absorption). Bioavailability is notably high (~90–95% absorption within 6 hours of ingestion) due to enzymatic hydrolysis reducing molecular weight; collagen peptides are detected in blood plasma within 1–2 hours post-ingestion. Pro-Hyp dipeptides have been measured at peak plasma concentrations of ~30–60 nmol/mL after a 10 g dose. No fiber, no cholesterol, and typically free of allergens (though fish-derived variants may affect those with fish allergies). Contains no added sugars, and is gluten-free. Ash content typically <2%.
Reported Mechanism (Provisional)
Peptan's bioactive peptides, particularly proline-hydroxyproline dipeptides, are absorbed intact and accumulate in target tissues. These peptides activate fibroblast proliferation and stimulate endogenous collagen synthesis through upregulation of COL1A1 and COL1A2 genes. The peptides also modulate matrix metalloproteinase activity, reducing collagen degradation.
Clinical Narrative (Provisional)
Multiple randomized controlled trials with 50-120 participants demonstrate Peptan's efficacy over 8-24 weeks. Studies show 20% increase in skin hydration, 13% reduction in wrinkle depth with 2.5-5g daily doses. Joint studies report 40% reduction in activity-related joint discomfort in athletes. Evidence quality is moderate with consistent results across independent research groups.
Also Known As
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