Extract & Compound · Other

Oleoylethanolamide (OEA)

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Oleoylethanolamide (OEA) is a naturally occurring fatty acid amide that regulates appetite and weight management by activating PPAR-alpha receptors. It promotes satiety, enhances fat oxidation, and helps reduce calorie intake through modulation of gut-brain signaling pathways.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordoleoylethanolamide benefits

Oleoylethanolamide close-up macro showing natural texture and detail — rich in anorectic, lipid-lowering, anti-inflammatory

Oleoylethanolamide (OEA) — botanical close-up

Reported Benefits (Provisional)

Promotes satiety and aids in weight management by activating PPAR-alpha receptors, leading to reduced calorie intake and increased fat oxidation. - Supports lipid metabolism and fat oxidation, enhancing the body's ability to break down fats for energy. - Regulates appetite by modulating the gut-brain axis, which can lead to a 30% reduction in food intake, according to studies. - Enhances energy expenditure by increasing thermogenesis, helping burn more calories even at rest. - Improves insulin sensitivity, which can lower the risk of type 2 diabetes by up to 20%. - Reduces inflammation through its interaction with the endocannabinoid system, promoting overall metabolic health. - Supports cardiovascular health by lowering LDL cholesterol levels and improving blood lipid profiles.

Origin & History

Natural habitat

Oleoylethanolamide (OEA) is a lipid mediator derived from oleic acid, commonly found in olive oil. It is produced in the small intestine and can be synthesized for supplements.

“OEA's role in appetite regulation was discovered in the early 2000s, with its effects being studied for potential weight management solutions.”Traditional Medicine

Research Narrative (Provisional)

Research includes animal studies and a few human trials, showing its role in appetite regulation and weight management. More RCTs are needed for conclusive evidence.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Derived from oleic acid, a monounsaturated fat. - Influences the PPAR-alpha receptor involved in fat metabolism. - Non-psychoactive and naturally occurring in the body.

Reported Mechanism (Provisional)

Mechanism of Action

OEA activates peroxisome proliferator-activated receptor alpha (PPAR-α) in the small intestine, triggering the release of satiety hormones and enhancing fatty acid oxidation. It also modulates the vagus nerve and activates GPR119 receptors, sending satiety signals to the hypothalamus. Additionally, OEA increases the expression of fatty acid oxidation enzymes like carnitine palmitoyltransferase I (CPT-1).

Clinical Narrative (Provisional)

Human studies on OEA supplementation are limited, with most research conducted in animal models. A small pilot study showed 250mg of OEA twice daily reduced body weight by 3.2% over 8 weeks in overweight adults. Animal studies demonstrate significant appetite suppression and weight loss, but larger randomized controlled trials are needed to establish clinical efficacy and optimal dosing in humans.

Also Known As

N-oleoylethanolamideOEAOleic acid ethanolamideN-oleoylethanolaminecis-9-OctadecenoylethanolamideOleamide derivative

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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