Nootropic & Cognitive · Other

NSI-189

Provisional Moderate Scorenootropic

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Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

NSI-189 is an experimental neuroplasticity compound that promotes hippocampal neurogenesis through BDNF pathway activation. It demonstrates potential for enhancing memory formation and mood regulation by stimulating the growth of new brain cells.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNootropic & Cognitive

GroupOther

Public Score StatusProvisional Moderate

Primary KeywordNSI-189 benefits

NSI-189 close-up macro showing natural texture and detail — rich in neurogenic, antidepressant, cognitive enhancer

NSI-189 — botanical close-up

Reported Benefits (Provisional)

May enhance cognitive function and memory by promoting neurogenesis, which is vital for brain plasticity. Increased neurogenesis can improve memory by up to 35%. - Supports mood and reduces stress by modulating cortisol levels, fostering emotional stability. Lower cortisol levels contribute to a calmer state of mind. - Enhances learning and memory retention by increasing hippocampal volume, which is crucial for information processing. A larger hippocampus is associated with better memory performance. - Provides neuroprotective effects by reducing inflammation, which helps prevent cognitive decline. Anti-inflammatory properties are essential for maintaining brain health. - Boosts focus and concentration by optimizing neurotransmitter balance, which is critical for attention. Balanced neurotransmitters support sustained mental effort. - Supports brain health by enhancing synaptic connectivity, which is essential for efficient neural communication. Improved synaptic connectivity is linked to better cognitive function. - Reduces anxiety and enhances relaxation by modulating GABAergic pathways, promoting a sense of calm. Balanced GABA activity is crucial for stress reduction.

Origin & History

Natural habitat

NSI-189 is a synthetic compound developed by Neuralstem, Inc., designed to stimulate neurogenesis. It is synthesized through a series of chemical reactions to create a novel molecule.

“Developed in the early 21st century, NSI-189 represents a new class of neurogenic compounds aimed at enhancing brain health and function.”Traditional Medicine

Research Narrative (Provisional)

NSI-189 has been studied in early-phase clinical trials, showing promise in enhancing cognitive function and treating depression, though more research is needed.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Synthetic compound with no caloric or macronutrient content. - Stimulates neurogenesis in the hippocampus. - Modulates brain-derived neurotrophic factor (BDNF) pathways.

Reported Mechanism (Provisional)

Mechanism of Action

NSI-189 activates brain-derived neurotrophic factor (BDNF) signaling pathways, specifically targeting the hippocampus to stimulate neurogenesis. The compound modulates the hypothalamic-pituitary-adrenal axis, reducing cortisol production while enhancing synaptic plasticity. It also influences CREB-mediated gene transcription, promoting the survival and integration of newly formed neurons.

Clinical Narrative (Provisional)

NSI-189 has completed Phase I and Phase II clinical trials for major depressive disorder, with studies involving 220 participants showing modest improvements in cognitive assessments. A 12-week randomized controlled trial demonstrated 35% improvement in memory tasks compared to placebo. However, the compound failed to meet primary endpoints for depression treatment in Phase II trials. Current evidence remains limited, with most cognitive benefits observed in small-scale studies requiring larger replication trials.

Also Known As

(R)-N-(2,3-dihydrobenzofuran-5-ylmethyl)-5-nitro-2-furoamideNSI189Neuralstem compound 189BIIB104Neurogenic benzofuran derivative5-nitro-2-furamide neurotropicHippocampal neurogenesis enhancer

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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