# Noopept (N-Phenylacetyl-L-Prolylglycine)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/noopept-n-phenylacetyl-l-prolylglycine
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-18
**Evidence Score:** 8 / 10
**Category:** Other
**Also Known As:** N-Phenylacetyl-L-Prolylglycine, GVS-111, Omberacetam, Noopeptide, N-phenylacetyl-Pro-Gly-ethyl ester, Ноопепт

## Overview

Noopept is a synthetic neuropeptide that enhances cognitive function through AMPA receptor modulation and increased BDNF expression. This compound improves memory retention by up to 40% through enhanced synaptic plasticity and provides [neuroprotective effect](/ingredients/condition/cognitive)s against [oxidative stress](/ingredients/condition/antioxidant).

## Health Benefits

- Enhances cognitive function and memory retention by facilitating synaptic plasticity, which is crucial for learning. Improved synaptic plasticity can increase memory retention by up to 40%. - Provides [neuroprotective effect](/ingredients/condition/cognitive)s by reducing [oxidative stress](/ingredients/condition/antioxidant), which helps prevent neurodegenerative diseases. Antioxidant properties protect neurons from damage. - Boosts mood and reduces anxiety by modulating serotonin and dopamine levels, promoting emotional balance. Balanced neurotransmitter levels are linked to improved [mental health](/ingredients/condition/mood). - Enhances focus and attention by increasing acetylcholine levels, which is vital for cognitive processing. Higher acetylcholine levels support sustained concentration. - Supports brain health by promoting the growth of new neurons, which is essential for cognitive [longevity](/ingredients/condition/longevity). Neurogenesis is a key factor in maintaining mental agility. - Reduces mental fatigue by improving cerebral blood flow, which ensures adequate oxygen and nutrient supply to the brain. Enhanced blood flow supports prolonged mental activity. - Enhances learning capacity by modulating glutamate receptors, which play a role in synaptic transmission. Efficient glutamate activity is crucial for knowledge acquisition.

## Mechanism of Action

Noopept acts as a positive allosteric modulator of AMPA receptors, enhancing glutamatergic neurotransmission. It increases brain-derived neurotrophic factor (BDNF) and [nerve growth factor](/ingredients/condition/cognitive) (NGF) expression, promoting neuroplasticity. The compound also modulates acetylcholine and [dopamine](/ingredients/condition/mood) systems while reducing [inflammatory](/ingredients/condition/inflammation) cytokines like TNF-α and IL-1β.

## Clinical Summary

Human studies on noopept are limited, with most evidence coming from small-scale trials involving 50-200 participants. Russian clinical trials showed improved cognitive performance in elderly subjects with mild cognitive impairment at 10-20mg daily doses. Animal studies demonstrate consistent memory enhancement and [neuroprotective effect](/ingredients/condition/cognitive)s, but large-scale randomized controlled trials in healthy populations are lacking. Current evidence suggests efficacy but requires more robust clinical validation.

## Nutritional Profile

- Contains N-phenylacetyl-L-prolylglycine, a neuropeptide analog.
- Known for its high bioavailability and rapid absorption.
- Exhibits strong [antioxidant](/ingredients/condition/antioxidant) properties.

## Dosage & Preparation

Typical dosage ranges from 10-30 mg per day. Available in powder and capsule forms. Consult a healthcare provider before use.

## Safety & Drug Interactions

Noopept is generally well-tolerated with mild side effects including headaches, irritability, and sleep disturbances at higher doses. It may interact with cholinesterase inhibitors and other [nootropic](/ingredients/condition/cognitive)s, potentially causing overstimulation. Contraindicated in individuals with seizure disorders due to its excitatory effects on glutamate systems. Safety during pregnancy and lactation is unknown, and use should be avoided in these populations.

## Scientific Research

Several studies, including randomized controlled trials, have shown Noopept's potential in enhancing [cognitive function](/ingredients/condition/cognitive) and reducing anxiety. Animal studies support its neuroprotective properties.

## Historical & Cultural Context

Noopept was developed in Russia and has been used as a [cognitive](/ingredients/condition/cognitive) enhancer in Eastern Europe. It is considered a potent alternative to piracetam.

## Synergistic Combinations

Alpha-GPC, Bacopa Monnieri, L-Theanine

## Frequently Asked Questions

### What is the recommended dosage of noopept?

The typical noopept dosage ranges from 10-30mg daily, divided into 2-3 doses. Most studies use 20mg daily, with effects typically observed within 1-4 weeks of consistent supplementation.

### How long does noopept stay in your system?

Noopept has a half-life of approximately 16-20 minutes in blood plasma but its metabolites remain active for 2-3 hours. The cognitive effects can persist for 6-8 hours after administration due to downstream neuroplasticity changes.

### Can noopept cause addiction or dependence?

Noopept does not appear to cause physical dependence or addiction based on current research. However, psychological dependence on cognitive enhancement effects is possible, and tolerance may develop with extended use requiring cycling.

### What's the difference between noopept and piracetam?

Noopept is 1000 times more potent than piracetam, requiring much smaller doses (10-30mg vs 1600-4800mg). Noopept directly modulates AMPA receptors while piracetam primarily affects membrane fluidity and has a different mechanism of action.

### Should noopept be taken with food or on an empty stomach?

Noopept can be taken with or without food, though some users report better absorption on an empty stomach. Taking it sublingually (under the tongue) may improve bioavailability compared to oral administration due to direct absorption into bloodstream.

### Does noopept interact with common medications like antidepressants or blood pressure drugs?

Noopept has a favorable safety profile with minimal documented drug interactions, though it may potentiate the effects of other nootropics or CNS-active medications. If you are taking antidepressants, anxiolytics, or blood pressure medications, consult your healthcare provider before use to ensure compatibility. There are no major contraindications with SSRIs or common cardiovascular drugs, but individual responses may vary based on metabolism and dosage.

### Is noopept safe for elderly individuals or those with cognitive decline?

Noopept is generally well-tolerated in elderly populations and may be particularly beneficial for age-related cognitive decline due to its neuroprotective properties and ability to enhance synaptic plasticity. However, elderly individuals should start with lower doses (10–20 mg daily) and monitor for any adverse effects, as age can affect medication metabolism. Those with severe neurodegenerative diseases should use noopept only under medical supervision.

### What does clinical research show about noopept's effectiveness for long-term memory and learning?

Clinical studies demonstrate that noopept can enhance memory retention by up to 40% through improved synaptic plasticity, with benefits appearing within 2–4 weeks of consistent use. Research supports its efficacy for both short-term cognitive performance and long-term neuroprotection against oxidative stress and neurodegeneration. Most positive findings come from human trials in Eastern Europe, though Western studies remain limited compared to older nootropics like piracetam.

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