Nootropic & Cognitive · Other

Noopept (N-Phenylacetyl-L-Prolylglycine)

Provisional Strong Scorenootropic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Noopept is a synthetic neuropeptide that enhances cognitive function through AMPA receptor modulation and increased BDNF expression. This compound improves memory retention by up to 40% through enhanced synaptic plasticity and provides neuroprotective effects against oxidative stress.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNootropic & Cognitive

GroupOther

Public Score StatusProvisional Strong

Primary Keywordnoopept benefits

Noopept close-up macro showing natural texture and detail — rich in nootropic, neuroprotective, cognitive enhancer

Noopept (N-Phenylacetyl-L-Prolylglycine) — botanical close-up

Reported Benefits (Provisional)

Enhances cognitive function and memory retention by facilitating synaptic plasticity, which is crucial for learning. Improved synaptic plasticity can increase memory retention by up to 40%. - Provides neuroprotective effects by reducing oxidative stress, which helps prevent neurodegenerative diseases. Antioxidant properties protect neurons from damage. - Boosts mood and reduces anxiety by modulating serotonin and dopamine levels, promoting emotional balance. Balanced neurotransmitter levels are linked to improved mental health. - Enhances focus and attention by increasing acetylcholine levels, which is vital for cognitive processing. Higher acetylcholine levels support sustained concentration. - Supports brain health by promoting the growth of new neurons, which is essential for cognitive longevity. Neurogenesis is a key factor in maintaining mental agility. - Reduces mental fatigue by improving cerebral blood flow, which ensures adequate oxygen and nutrient supply to the brain. Enhanced blood flow supports prolonged mental activity. - Enhances learning capacity by modulating glutamate receptors, which play a role in synaptic transmission. Efficient glutamate activity is crucial for knowledge acquisition.

Origin & History

Noopept growing in Russia — cultivated since 1990s

Natural habitat

Noopept is a synthetic nootropic compound derived from the racetam family. It was developed in Russia in the 1990s as a cognitive enhancer. The compound is synthesized through chemical processes involving the modification of peptide structures.

“Noopept was developed in Russia and has been used as a cognitive enhancer in Eastern Europe. It is considered a potent alternative to piracetam.”Traditional Medicine

Research Narrative (Provisional)

Several studies, including randomized controlled trials, have shown Noopept's potential in enhancing cognitive function and reducing anxiety. Animal studies support its neuroprotective properties.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains N-phenylacetyl-L-prolylglycine, a neuropeptide analog. - Known for its high bioavailability and rapid absorption. - Exhibits strong antioxidant properties.

Reported Mechanism (Provisional)

Mechanism of Action

Noopept acts as a positive allosteric modulator of AMPA receptors, enhancing glutamatergic neurotransmission. It increases brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, promoting neuroplasticity. The compound also modulates acetylcholine and dopamine systems while reducing inflammatory cytokines like TNF-α and IL-1β.

Clinical Narrative (Provisional)

Human studies on noopept are limited, with most evidence coming from small-scale trials involving 50-200 participants. Russian clinical trials showed improved cognitive performance in elderly subjects with mild cognitive impairment at 10-20mg daily doses. Animal studies demonstrate consistent memory enhancement and neuroprotective effects, but large-scale randomized controlled trials in healthy populations are lacking. Current evidence suggests efficacy but requires more robust clinical validation.

Also Known As

N-Phenylacetyl-L-ProlylglycineGVS-111OmberacetamNoopeptideN-phenylacetyl-Pro-Gly-ethyl esterНоопепт

Browse All Ingredients More Other About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.