Extract & Compound · Compound

Naringenin

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Naringenin is a flavonoid polyphenol found primarily in citrus fruits that demonstrates cardiovascular and metabolic benefits through PPAR-α activation and NF-κB inhibition. This bioactive compound reduces LDL cholesterol levels and inflammatory markers while improving insulin sensitivity.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordnaringenin benefits

Naringenin close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, estrogenic

Naringenin — botanical close-up

Reported Benefits (Provisional)

Supports cardiovascular health by improving lipid profiles, reducing LDL cholesterol by up to 15% and increasing HDL cholesterol. - Exhibits anti-inflammatory properties by inhibiting NF-kB pathways, reducing chronic inflammation and associated diseases. - Enhances metabolic health by improving insulin sensitivity, aiding in better blood sugar control. - Supports liver health by promoting detoxification processes, reducing the risk of liver diseases. - Boosts immune function by enhancing the activity of immune cells, providing better protection against pathogens. - Promotes skin health by reducing oxidative stress, leading to a clearer and more youthful complexion. - Aids in weight management by increasing fat oxidation, potentially reducing body fat.

Origin & History

Natural habitat

Naringenin is a flavonoid predominantly found in citrus fruits like grapefruits and oranges. It is extracted through solvent extraction and purification processes. The compound is known for its antioxidant properties and is often used in dietary supplements.

“Naringenin has been used in traditional medicine systems for its health-promoting properties, particularly in managing inflammation and metabolic disorders. Its discovery dates back to the isolation of flavonoids in the early 20th century.”Traditional Medicine

Research Narrative (Provisional)

Multiple in vitro and animal studies suggest naringenin's efficacy in reducing oxidative stress and improving metabolic health. Human trials are limited but promising, especially in cardiovascular and metabolic health.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains potent antioxidant flavonoids. - Rich in vitamin C and other citrus-derived nutrients. - Low in calories and sugars, making it suitable for various diets.

Reported Mechanism (Provisional)

Mechanism of Action

Naringenin activates peroxisome proliferator-activated receptor-alpha (PPAR-α), enhancing fatty acid oxidation and improving lipid metabolism. It inhibits nuclear factor-kappa B (NF-κB) signaling pathways, reducing pro-inflammatory cytokine production including TNF-α and IL-6. The compound also modulates AMP-activated protein kinase (AMPK) activity, promoting glucose uptake and insulin sensitivity.

Clinical Narrative (Provisional)

Human studies involving 50-120 participants show naringenin supplementation (400-600mg daily) reduces LDL cholesterol by 10-15% over 8-12 weeks. Randomized controlled trials demonstrate significant decreases in inflammatory markers including C-reactive protein and interleukin-6 levels. Limited clinical evidence supports metabolic benefits, with small studies showing improved insulin sensitivity in prediabetic individuals. Most research relies on animal models and in vitro studies, requiring more robust human clinical trials.

Also Known As

4',5,7-TrihydroxyflavanoneNaringetolSalipurposidePelargidanon5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-oneCitrus flavonoidAspalathol

Browse All Ingredients More Compound About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.