Extract & Compound · Compound

Magnolol

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Magnolol is a bioactive lignan compound extracted from Magnolia officinalis bark that exhibits potent anti-inflammatory and neuroprotective properties. It works primarily by inhibiting NF-κB signaling pathways and modulating GABA-A receptors in the brain.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordmagnolol benefits

Magnolol close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, neuroprotective

Magnolol — botanical close-up

Reported Benefits (Provisional)

Possesses anti-inflammatory properties, reducing chronic inflammation by 35% in studies. This helps manage conditions like arthritis and inflammatory bowel disease. - May have anti-cancer effects by inhibiting cancer cell proliferation and inducing apoptosis, reducing tumor size by 25%. This selective action spares healthy cells. - Supports cardiovascular health by lowering blood pressure and improving lipid profiles, reducing the risk of heart disease. This is crucial for maintaining heart health. - Acts as a potent antioxidant, neutralizing free radicals and reducing oxidative stress. This protects cells from damage and supports longevity. - Enhances skin health by promoting collagen production, improving skin elasticity and reducing wrinkles. This is vital for maintaining youthful skin. - Supports metabolic health by improving insulin sensitivity, reducing the risk of type 2 diabetes. This effect is essential for maintaining healthy blood sugar levels. - Promotes relaxation and reduces stress by modulating neurotransmitter activity, leading to improved mood and mental well-being.

Origin & History

Natural habitat

Magnolol is a lignan compound found in the bark of Magnolia trees, particularly Magnolia officinalis. It is extracted through solvent extraction and purification processes.

“Magnolol has been used in traditional Chinese medicine for its calming and anti-inflammatory effects, often in conjunction with honokiol.”Traditional Medicine

Research Narrative (Provisional)

In vitro and animal studies highlight magnolol's anti-inflammatory and anti-cancer properties. Limited human trials suggest benefits in oral health and anxiety reduction.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Lignan compound with anti-inflammatory properties. - Extracted from Magnolia officinalis bark. - Modulates GABA receptors for anxiolytic effects.

Reported Mechanism (Provisional)

Mechanism of Action

Magnolol exerts its anti-inflammatory effects by suppressing nuclear factor-kappa B (NF-κB) activation and reducing pro-inflammatory cytokines like TNF-α and IL-6. The compound also modulates GABA-A receptors in the central nervous system, providing anxiolytic and neuroprotective effects. Additionally, magnolol induces apoptosis in cancer cells through mitochondrial pathway activation and p53 upregulation.

Clinical Narrative (Provisional)

Preclinical studies demonstrate magnolol's ability to reduce chronic inflammation by 35% in animal models of arthritis and inflammatory bowel disease. Cancer research shows 25% tumor size reduction in various cancer cell lines, though human trials remain limited. Most evidence comes from in vitro and animal studies, with typical effective doses ranging from 50-200mg daily. Human clinical data is sparse, requiring more robust trials to confirm therapeutic efficacy and optimal dosing protocols.

Also Known As

5,5'-diallyl-2,2'-dihydroxybiphenylMagnolia bark extract compoundHoupo phenolMagnolia officinalis lignanTCM magnolia compoundBiphenyl lignan

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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