Enzyme

Lysozyme

Provisional Strong Scoreenzyme

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Lysozyme is an antimicrobial enzyme that cleaves peptidoglycan in bacterial cell walls, particularly targeting gram-positive bacteria. This glycoside hydrolase strengthens innate immunity by destroying harmful microbes while preserving beneficial bacteria.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryEnzyme

GroupEnzyme

Public Score StatusProvisional Strong

Primary Keywordlysozyme benefits

Lysozyme close-up macro showing natural texture and detail — rich in antibacterial, immune modulator, mucolytic

Lysozyme — botanical close-up

Reported Benefits (Provisional)

Supports immune function by breaking down bacterial cell walls, helping the body defend against harmful microbes. This enzymatic action enhances innate immunity and reduces infection risk.

Provides antimicrobial activity, targeting a broad range of bacteria and supporting a balanced microbiome. Studies show lysozyme can reduce pathogenic bacteria by up to 60%.

Promotes oral health by reducing harmful bacteria in the mouth, potentially lowering the risk of gum disease and cavities. Regular use supports fresher breath and healthier gums.

Aids in wound healing by preventing bacterial colonization and supporting tissue regeneration. This can accelerate recovery from minor cuts and abrasions.

May reduce inflammation by controlling bacterial populations that trigger immune responses. Balanced microbial environments are linked to lower systemic inflammation.

Supports respiratory health by helping to clear pathogens from mucosal surfaces

This can reduce the frequency and severity of respiratory infections.

Enhances gut barrier integrity by maintaining a healthy balance of gut flora

A strong gut barrier is crucial for overall immune defense.

May benefit individuals with compromised immunity by providing an extra layer of microbial protection.

Origin & History

Natural habitat

Lysozyme is an enzyme that breaks down bacterial cell walls, providing antimicrobial activity. It is naturally found in egg whites, human tears, and saliva, and can be extracted for commercial use. Lysozyme is used in food preservation and as a therapeutic agent for its immune-supporting properties.

“Discovered by Alexander Fleming in 1922, lysozyme has been recognized for its antimicrobial properties and used in various applications, including food preservation and medicine.”Traditional Medicine

Research Narrative (Provisional)

Lysozyme has been extensively studied in vitro and in animal models for its antimicrobial properties. Some human trials suggest immune-supporting benefits, but more research is needed.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Enzyme activity measured in units per milligram (U/mg). - Contains protein structures essential for its antimicrobial function. - Often included in immune-supporting supplements and formulations.

Reported Mechanism (Provisional)

Mechanism of Action

Lysozyme cleaves the β(1-4) glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in bacterial peptidoglycan layers. This hydrolytic action disrupts cell wall integrity, causing bacterial lysis and death. The enzyme shows selectivity for gram-positive bacteria due to their exposed peptidoglycan layer.

Clinical Narrative (Provisional)

Limited human clinical trials exist for lysozyme supplementation, with most research conducted in vitro or animal models. Studies on lysozyme-rich lactoferrin preparations show 20-30% reduction in respiratory infections in groups of 50-100 participants. Animal studies demonstrate enhanced immune cell activity and reduced bacterial colonization at doses of 10-50mg/kg. More robust human trials are needed to establish definitive therapeutic benefits.

Also Known As

MuramidaseN-acetylmuramide glycanhydrolasePeptidoglycan N-acetylmuramoylhydrolaseFleming's enzymeMucopeptide N-acetylmuramylhydrolaseEC 3.2.1.17

Browse All Ingredients More Enzyme About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.