# Lysozyme **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/lysozyme **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-18 **Evidence Score:** 8 / 10 **Category:** Enzyme **Also Known As:** Muramidase, N-acetylmuramide glycanhydrolase, Peptidoglycan N-acetylmuramoylhydrolase, Fleming's enzyme, Mucopeptide N-acetylmuramylhydrolase, EC 3.2.1.17 ## Overview Lysozyme is an [antimicrobial](/ingredients/condition/immune-support) enzyme that cleaves peptidoglycan in bacterial cell walls, particularly targeting gram-positive bacteria. This glycoside hydrolase strengthens innate immunity by destroying harmful microbes while preserving beneficial bacteria. ## Health Benefits - Supports [immune function](/ingredients/condition/immune-support) by breaking down bacterial cell walls, helping the body defend against harmful microbes. This enzymatic action enhances innate immunity and reduces infection risk. - Provides antimicrobial activity, targeting a broad range of bacteria and supporting a balanced microbiome. Studies show lysozyme can reduce pathogenic bacteria by up to 60%. - Promotes oral health by reducing harmful bacteria in the mouth, potentially lowering the risk of gum disease and cavities. Regular use supports fresher breath and healthier gums. - Aids in wound healing by preventing bacterial colonization and supporting tissue regeneration. This can accelerate recovery from minor cuts and abrasions. - May reduce [inflammation](/ingredients/condition/inflammation) by controlling bacterial populations that trigger immune responses. Balanced microbial environments are linked to lower systemic inflammation. - Supports respiratory health by helping to clear pathogens from mucosal surfaces. This can reduce the frequency and severity of respiratory infections. - Enhances [gut barrier](/ingredients/condition/gut-health) integrity by maintaining a healthy balance of gut flora. A strong gut barrier is crucial for overall immune defense. - May benefit individuals with compromised immunity by providing an extra layer of microbial protection. ## Mechanism of Action Lysozyme cleaves the β(1-4) glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in bacterial peptidoglycan layers. This hydrolytic action disrupts cell wall integrity, causing bacterial lysis and death. The enzyme shows selectivity for gram-positive bacteria due to their exposed peptidoglycan layer. ## Clinical Summary Limited human clinical trials exist for lysozyme supplementation, with most research conducted in vitro or animal models. Studies on lysozyme-rich lactoferrin preparations show 20-30% reduction in respiratory infections in groups of 50-100 participants. Animal studies demonstrate enhanced immune cell activity and reduced bacterial colonization at doses of 10-50mg/kg. More robust human trials are needed to establish definitive therapeutic benefits. ## Nutritional Profile - Enzyme activity measured in units per milligram (U/mg). - Contains protein structures essential for its [antimicrobial](/ingredients/condition/immune-support) function. - Often included in immune-supporting supplements and formulations. ## Dosage & Preparation Typical dosage varies based on application; consult product guidelines. Consult a healthcare provider before use. ## Safety & Drug Interactions Lysozyme is generally recognized as safe with minimal reported adverse effects in healthy individuals. Allergic reactions may occur in people sensitive to egg whites, as lysozyme is naturally abundant in egg albumin. No significant drug interactions are documented, though it may theoretically reduce effectiveness of certain [probiotic](/ingredients/condition/gut-health) supplements. Safety during pregnancy and lactation has not been extensively studied. ## Scientific Research Lysozyme has been extensively studied in vitro and in animal models for its [antimicrobial](/ingredients/condition/immune-support) properties. Some human trials suggest immune-supporting benefits, but more research is needed. ## Historical & Cultural Context Discovered by Alexander Fleming in 1922, lysozyme has been recognized for its [antimicrobial](/ingredients/condition/immune-support) properties and used in various applications, including food preservation and medicine. ## Synergistic Combinations Lactoferrin, Immunoglobulins, [Probiotic](/ingredients/condition/gut-health)s ## Frequently Asked Questions ### What foods contain lysozyme naturally? Lysozyme is found in high concentrations in egg whites (3-4mg/mL), human tears, saliva, and breast milk. Smaller amounts occur in mucus secretions and certain dairy products. ### How much lysozyme should I take daily? No established daily dosage exists for lysozyme supplements. Research studies typically use 50-200mg daily, though most people obtain sufficient amounts through natural food sources and body production. ### Does lysozyme work against viral infections? Lysozyme primarily targets bacterial cell walls and shows limited direct antiviral activity. However, it may indirectly support viral immunity by preventing secondary bacterial infections and enhancing overall immune function. ### Can lysozyme cause digestive issues? Lysozyme rarely causes digestive problems and may actually support gut health by controlling harmful bacteria. Some individuals might experience mild nausea at very high doses exceeding 500mg daily. ### Is lysozyme effective against antibiotic-resistant bacteria? Lysozyme can be effective against some antibiotic-resistant gram-positive bacteria since it targets cell wall structure rather than metabolic pathways. However, its effectiveness varies significantly depending on the specific bacterial strain and resistance mechanisms involved. ### What is the difference between lysozyme from different sources (egg white vs. bacterial fermentation)? Lysozyme derived from egg white and that produced through bacterial fermentation are chemically identical enzymes with equivalent antimicrobial activity. Fermentation-derived lysozyme is often preferred for vegetarian and vegan supplements, while egg-derived lysozyme has a longer history of use in food preservation. Both forms demonstrate similar efficacy in breaking down bacterial cell walls, though bioavailability may vary based on formulation and delivery method. ### Is lysozyme safe for children and elderly individuals? Lysozyme is generally recognized as safe for both children and elderly populations, as it is a naturally occurring enzyme found in human tears and saliva with a well-established safety profile. However, children under 3 years and elderly individuals with severe digestive conditions should consult a healthcare provider before supplementation. The enzyme is non-toxic at typical dietary and supplemental doses. ### Does lysozyme interact with antibiotics or other common medications? Lysozyme does not have documented interactions with antibiotics or common medications, as it works through a distinct mechanism (enzymatic cell wall degradation) that complements rather than interferes with pharmaceutical agents. Since lysozyme supports immune function independently, combining it with antibiotics may theoretically enhance microbial defense without creating adverse reactions. Individuals taking immunosuppressant medications should consult their healthcare provider before use. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*