Hermetica Superfood Encyclopedia
The Short Answer
Lactobacillus reuteri DSM 17938 is a clinically studied probiotic strain that produces reuterin, an antimicrobial compound that helps balance gut microbiota. This strain modulates immune function through toll-like receptor signaling and supports digestive health by enhancing intestinal barrier integrity.
CategoryProbiotic & Fiber
GroupClinical Probiotic
Evidence LevelStrong
Primary KeywordLactobacillus reuteri DSM 17938 benefits
Synergy Pairings4
Lactobacillus reuteri DSM 17938 — botanical close-up
Health Benefits
Supports digestive health by balancing the gut microbiota, which is crucial for nutrient absorption and overall well-being. - Enhances immune function, reducing the risk of infections by increasing the production of protective antibodies. - Promotes mental well-being by influencing the gut-brain axis, potentially alleviating anxiety and depression. - Aids in weight management by regulating fat storage and energy expenditure, supporting a healthy body weight. - Improves skin health by reducing systemic inflammation, which can alleviate conditions like acne and eczema. - Supports cardiovascular health by reducing cholesterol levels, lowering the risk of heart disease. - Enhances energy metabolism by breaking down complex carbohydrates, improving energy levels and endurance.
Origin & History
Natural habitat
Lactobacillus reuteri DSM 17938 is a probiotic strain derived from the human gut microbiota. It is cultured through fermentation and is used in dietary supplements and functional foods.
“Discovered in the late 20th century, Lactobacillus reuteri DSM 17938 is a well-researched probiotic strain used in supplements and functional foods.”Traditional Medicine
Scientific Research
Lactobacillus reuteri DSM 17938 has been studied in multiple RCTs, showing efficacy in supporting digestive and immune health. Meta-analyses confirm its benefits in various health conditions.
Preparation & Dosage
Traditional preparation
Typical dosage ranges from 1 to 10 billion CFU per day. Consult a healthcare provider before use.
Nutritional Profile
- Contains live probiotic cultures. - Produces lactic acid, supporting gut health. - Rich in bioactive compounds that modulate the immune system.
How It Works
Mechanism of Action
Lactobacillus reuteri DSM 17938 produces reuterin (3-hydroxypropionaldehyde) from glycerol, which exhibits broad-spectrum antimicrobial activity against pathogenic bacteria while preserving beneficial microbes. The strain activates toll-like receptors (TLR2/TLR4) on intestinal epithelial cells, triggering anti-inflammatory cytokine production including IL-10. It also strengthens tight junction proteins like claudin-1 and occludin, improving intestinal barrier function and reducing inflammatory responses.
Clinical Evidence
Multiple randomized controlled trials have demonstrated the efficacy of L. reuteri DSM 17938, particularly in pediatric populations. Studies with 50-400 participants show significant reduction in infantile colic crying time by 50-80% within 21 days of supplementation. Adult trials (n=100-200) demonstrate improved digestive symptoms and reduced inflammatory markers after 4-8 weeks of daily administration. The evidence is strongest for gastrointestinal applications, with emerging research on immune and neurological benefits showing promising but preliminary results.
Safety & Interactions
Lactobacillus reuteri DSM 17938 is generally well-tolerated with minimal reported adverse effects, primarily mild digestive symptoms during initial use. No significant drug interactions have been documented, though individuals taking immunosuppressive medications should consult healthcare providers before use. The strain is contraindicated in severely immunocompromised patients and those with central venous catheters due to rare risk of bacteremia. Safety during pregnancy and lactation appears favorable based on limited studies, but more research is needed for definitive recommendations.
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Frequently Asked Questions
What is the effective dosage of Lactobacillus reuteri DSM 17938?
Clinical studies typically use doses of 1×10^8 CFU daily for adults and 1×10^8 CFU daily for infants. Most commercial supplements provide this dosage in 5-10 drops of oil suspension or one capsule. Treatment duration ranges from 21 days to 12 weeks depending on the condition being addressed.
How long does it take for Lactobacillus reuteri DSM 17938 to work?
Effects on digestive symptoms typically appear within 7-14 days of consistent use, with maximum benefits observed after 21 days. For immune system support, clinical improvements may take 4-8 weeks. Individual response varies based on baseline gut microbiota composition and overall health status.
Can Lactobacillus reuteri DSM 17938 survive stomach acid?
This strain demonstrates good acid tolerance and can survive gastric transit to reach the intestines viable. Studies show approximately 10-30% of ingested bacteria remain viable after passing through stomach acid. Taking with food may further improve survival rates through buffering stomach pH.
Is Lactobacillus reuteri DSM 17938 safe for infants?
Yes, extensive clinical research supports safety in infants as young as newborns, with over 1,000 infants studied across multiple trials. The strain is naturally found in human breast milk and has GRAS (Generally Recognized as Safe) status. No serious adverse events have been reported in pediatric studies.
What makes DSM 17938 different from other Lactobacillus reuteri strains?
DSM 17938 is derived from the original ATCC 55730 strain but has had antibiotic resistance genes removed for safety. It retains the ability to produce reuterin antimicrobial compounds while being genomically stable. This specific strain has the most extensive clinical research documentation among L. reuteri variants.
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