Kaishore Guggulu

Kaishore Guggulu is a traditional Ayurvedic polyherbal-mineral formulation, not a food, so standard macronutrient profiling (carbohydrates, fats, protein) is not directly applicable at typical dosage (250–500 mg tablets, 1–2 tablets twice daily). Key bioactive compounds and constituents include: Guggulsterones (Z- and E-isomers): approximately 2.5–5% w/w of guggul resin (Commiphora mukul); primary anti-inflammatory and hypolipidemic actives; moderate oral bioavailability (~40–50%) enhanced by co-formulated piperine from Piper longum. Curcuminoids (from Haridra/Curcuma longa): approximately 2–5% curcumin content in the turmeric ingredient; anti-inflammatory and antioxidant; inherently low bioavailability (~1–2%) but improved by piperine (up to 2000% enhancement). Piperine (from Pippali/Piper longum and Maricha/Piper nigrum): approximately 3–9% in pepper ingredients; serves as bioenhancer for curcumin and guggulsterones. Gallic acid and ellagic acid (from Triphala components – Amalaki, Bibhitaki, Haritaki): Amalaki contributes significant Vitamin C (~300–600 mg per 100 g of amla fruit powder); ellagitannins ~1–2% w/w; chebulagic acid and chebulinic acid from Haritaki ~2–4% w/w. Berberine and related alkaloids (from Daruharidra/Berberis aristata): approximately 2–5% berberine content; bioavailability ~5% orally; exhibits antimicrobial and hepatoprotective activity. Giloy/Guduchi (Tinospora cordifolia): contains tinosporin, berberine, palmatine, and polysaccharides (arabinogalactan); immunomodulatory diterpenoids ~0.5–1%. Mineral content: trace iron, calcium, and zinc contributed by herbal ash and guggul resin; iron ~0.5–2 mg per gram of formulation depending on manufacturer. Gum resin components: myrrhanone, myrrhanol, and mukulol from guggul resin providing additional anti-arthritic activity. Fiber: negligible at therapeutic doses (~1–2 g/day total intake). Calories: negligible (<5 kcal per daily dose). Note on bioavailability: The polyherbal synergy, particularly the inclusion of piperine-containing herbs, is traditionally designed to enhance the absorption of otherwise poorly bioavailable compounds like curcumin and guggulsterones. The triphala component may also enhance gut absorption through its mild laxative and prebiotic effects on intestinal mucosa.