Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Jaboticaba (Myrciaria cauliflora) is a Brazilian fruit whose dark purple peel contains high concentrations of cyanidin-3-glucoside and ellagic acid derivatives with demonstrated anti-cancer activity. The peel extract exhibits anti-proliferative effects against colorectal cancer cells at IC50 concentrations of 0.14-1.3 mg/mL through EGFR downregulation and apoptosis induction.
Reported Benefits (Provisional)
Origin & History
Jaboticaba (Myrciaria cauliflora or Plinia cauliflora) is a unique fruit tree native to the Atlantic rainforest biome of southeastern Brazil, also found in parts of Paraguay, Argentina, and Bolivia. Known for its distinctive growth pattern where fruits emerge directly from the trunk, it thrives in nutrient-rich, well-drained soils. This deeply pigmented fruit is a powerhouse of anthocyanins, offering significant functional benefits for cardiovascular, digestive, and skin health.
Research Narrative (Provisional)
Scientific studies, including in vitro and animal models, have demonstrated Jaboticaba's cardiovascular benefits through lipid regulation and arterial relaxation. Research also indicates significant anti-inflammatory activity and preliminary evidence for inducing apoptosis in certain cancer cell lines, suggesting chemopreventive potential. While promising, human clinical trials are ongoing to fully establish its therapeutic efficacy.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Dietary Fiber: Promotes gut health and satiety. - Vitamin C: Enhances immune function and supports skin health. - Anthocyanins: High levels of delphinidin, cyanidin, and malvidin, providing potent antioxidant and anti-inflammatory effects. - Polyphenols: Including ellagic acid, tannins, quercetin, and other flavonols, contributing to anti-inflammatory and astringent properties. - Trace Minerals: Iron, zinc, and manganese, supporting various metabolic functions.
Reported Mechanism (Provisional)
Jaboticaba's primary bioactive compound cyanidin-3-glucoside downregulates EGFR expression in cancer cells, promoting apoptosis and reducing angiogenesis. The ellagic acid derivative 3,3′-dimethylellagic acid-4-O-sulfate and depside jaboticabin inhibit IL-8 production in airway epithelial cells while providing antioxidant activity through ABTS radical scavenging. Phenolic compounds destabilize bacterial cell walls and denature proteins, contributing to antimicrobial effects.
Clinical Narrative (Provisional)
Human clinical evidence remains limited to one randomized crossover trial demonstrating improved serum antioxidant capacity and plasma GLP-1 response following carbohydrate meals in healthy adults. Preclinical studies show stronger evidence, with aqueous peel extracts achieving IC50 values of 1.2-1.3 mg/mL against Caco-2 colorectal cancer cells and inhibiting colony formation at 1-2 mg/mL concentrations. Animal models have confirmed cardiovascular benefits through lipid regulation and arterial relaxation, though human trials are ongoing. The evidence strength is currently moderate for antioxidant effects but requires additional clinical validation for anti-cancer applications.
Also Known As
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