Japanese Kampo Medicine · Other

Houttuynia cordata (Dokudami)

Provisional Moderate Scorebotanical

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Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Houttuynia cordata is a Japanese herb containing quercetin and other flavonoids that modulate immune function and reduce inflammation. It works by inhibiting NF-κB signaling pathways and enhancing macrophage activity.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryJapanese Kampo Medicine

GroupOther

Public Score StatusProvisional Moderate

Primary KeywordHouttuynia cordata benefits

Houttuynia cordata close-up macro showing natural texture and detail — rich in antiviral, antibacterial, anti-inflammatory

Houttuynia cordata (Dokudami) — botanical close-up

Reported Benefits (Provisional)

Supports immune health by enhancing white blood cell activity, providing robust defense against infections. - Reduces inflammation by inhibiting pro-inflammatory pathways, promoting joint and muscle health. - Aids in detoxification by supporting liver function, facilitating toxin elimination. - Enhances skin health by reducing oxidative stress, leading to a clearer complexion. - Supports respiratory health by acting as a natural expectorant, easing breathing. - Improves digestion by promoting healthy gut flora, aiding in nutrient absorption. - Alleviates allergy symptoms by modulating immune response, reducing sensitivity to allergens.

Origin & History

Natural habitat

Houttuynia cordata, also known as Dokudami, is a perennial herb native to Southeast Asia. It is often used fresh or dried in traditional medicine preparations.

“Houttuynia cordata has been used in traditional Asian medicine for centuries, valued for its detoxifying and healing properties. It is a staple in both culinary and medicinal practices across various cultures.”Traditional Medicine

Research Narrative (Provisional)

Studies have shown that Houttuynia cordata possesses antimicrobial and anti-inflammatory properties, with some research supporting its use in treating infections. However, more clinical trials are necessary to confirm these effects.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

{"macronutrients": {"protein": "1.4 g per 100 g", "fiber": "2.7 g per 100 g"}, "micronutrients": {"vitamin_C": "25 mg per 100 g", "calcium": "77 mg per 100 g", "potassium": "390 mg per 100 g", "iron": "1.2 mg per 100 g"}, "bioactive_compounds": {"quercitrin": "0.5 mg per 100 g", "hyperin": "0.3 mg per 100 g", "chlorogenic_acid": "0.2 mg per 100 g"}, "bioavailability_notes": "The bioavailability of quercitrin and hyperin may be enhanced when consumed with fats, while vitamin C is water-soluble and readily absorbed."}

Reported Mechanism (Provisional)

Mechanism of Action

Houttuynia cordata's bioactive compounds, including quercetin, chlorogenic acid, and rutin, inhibit nuclear factor-κB (NF-κB) inflammatory pathways and cyclooxygenase-2 (COX-2) enzymes. The herb enhances phagocytic activity of macrophages and increases interleukin-2 production for immune support. Its hepatoprotective effects involve upregulating glutathione S-transferase and other phase II detoxification enzymes.

Clinical Narrative (Provisional)

Limited human studies exist, with most research conducted in animal models and cell cultures. A small 2018 study (n=45) showed 15% reduction in inflammatory markers after 8 weeks of supplementation. Animal studies demonstrate significant anti-inflammatory effects at 200-400mg/kg doses. More robust human clinical trials are needed to establish definitive therapeutic benefits and optimal dosing protocols.

Also Known As

Houttuynia cordataFish MintFish LeafChameleon PlantRainbow PlantYuxingcaoLizard TailBishop's Weed

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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