Fruit

Gandaria

Provisional Moderate ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Gandaria seeds are rich in bioactive phenolic compounds, notably gallotannins such as gallic acid and penta-O-galloyl-β-D-glucose. These compounds are responsible for its potent antioxidant, anticancer (inducing apoptosis and cell cycle arrest), and potential antidiabetic effects by modulating various cellular pathways.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryFruit

GroupFruit

Public Score StatusProvisional Moderate

Primary Keywordgandaria benefits

Gandaria close-up macro showing natural texture and detail — rich in primary mechanisms include antioxidant activity through phenolic compounds and vitamin c, antimicrobial effects via unspecified bioactive compounds, and potential alpha-glucosidase inhibition contributing to glucose regulation. limited data available on specific cyp450 interactions

Gandaria — botanical close-up

Reported Benefits (Provisional)

Supports immune function through antimicrobial, antiviral, and antioxidant compounds.

Enhances digestive health by promoting gut microbiome balance and enzymatic activity.

Regulates blood sugar levels by optimizing insulin sensitivity

Promotes cardiovascular health by improving circulation and reducing oxidative stress.

Provides neuroprotective benefits by mitigating oxidative damage

Facilitates liver detoxification and supports metabolic balance

Promotes skin rejuvenation through enhanced collagen synthesis and antioxidant protection.

Origin & History

Natural habitat

Gandaria (Bouea macrophylla) is a tropical fruit native to Southeast Asia, particularly Indonesia, Malaysia, Thailand, and the Philippines. Flourishing in humid climates with well-drained soils, it has been traditionally revered for its potent antioxidant, immune-boosting, and digestive-supporting properties. It is valued in functional nutrition for its comprehensive wellness benefits.

“Historically celebrated in Malay, Javanese, and Thai healing traditions, Gandaria is revered as a botanical of vitality, digestive harmony, and immune resilience. Its deep-rooted role in traditional diets and medicinal preparations reflects its significance in sustaining holistic health.”Traditional Medicine

Research Narrative (Provisional)

Preliminary research, including in vitro studies, highlights Gandaria's antioxidant potency, cardiovascular support, and potential for metabolic regulation and gut microbiome enhancement. Studies suggest its ability to reduce systemic inflammation and fortify immune defenses, though human clinical trials are limited.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Prebiotic fibers, Digestive enzymes - Calcium, Magnesium, Potassium - Vitamins A, C, E - Flavonoids, Polyphenols, Carotenoids, Tannins, Saponins

Reported Mechanism (Provisional)

Mechanism of Action

Gandaria's health benefits are primarily attributed to its phenolic compounds, specifically gallotannins like gallic acid (GA), ethyl gallate (EG), and penta-O-galloyl-β-D-glucose (PGG), alongside flavonoids. These compounds induce apoptosis in cancer cells by triggering cell cycle arrest (e.g., S-phase, G0/G1, G2/M) and modulating key regulatory proteins such as Bax/Bcl-2, cyclin D1, p27, p21, and p53. Furthermore, they inhibit pathways like JAK1-STAT3, contributing to their diverse anticancer and antioxidant effects.

Clinical Narrative (Provisional)

Preliminary in vitro studies highlight Gandaria's significant antioxidant potency, cardiovascular support, and potential for metabolic regulation and gut microbiome enhancement. Research indicates its anticancer properties, particularly its ability to induce apoptosis and cell cycle arrest in breast cancer cells, and suggests potential antidiabetic effects. While these findings are promising, robust human clinical trials are critically needed to validate efficacy, safety, and optimal dosages in vivo.

Also Known As

Bouea macrophyllaplum mango

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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