Dynamine (Methylliberine)

Dynamine (Methylliberine) is a purine alkaloid and synthetic/isolated compound, not a traditional food ingredient, and therefore contains no macronutrients (0g protein, 0g fat, 0g carbohydrates), no dietary fiber, no vitamins, and no minerals in supplemental form. Bioactive compound: Methylliberine (chemical formula C9H12N4O2, molecular weight 208.22 g/mol), a methylated derivative of liberine and structural analog of theacrine (TeaCrine). Typical supplemental dosing ranges from 25mg to 150mg per serving, with common efficacious doses cited at 100–150mg. It is frequently standardized to 40% methylliberine in commercial ingredient blends (e.g., as found in Enfinity brand). Mechanistically active via adenosine receptor antagonism and dopaminergic/noradrenergic pathway modulation, similar to but distinct from caffeine and theacrine. Bioavailability: Methylliberine is reported to have rapid onset of action (approximately 30–60 minutes post-ingestion) due to its lipophilic structure, which facilitates blood-brain barrier penetration. It does not appear to meaningfully inhibit CYP1A2 enzymes at standard doses, suggesting lower interaction risk with caffeine metabolism compared to some other alkaloids. No caloric value. Often co-formulated with caffeine (50–100mg) to produce synergistic stimulant effects. Research base is limited primarily to preclinical and early-stage human data as of 2024.