Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
D-mannose is a simple sugar that prevents urinary tract infections by blocking E. coli bacteria from adhering to bladder walls. This monosaccharide works through competitive inhibition at the FimH adhesin receptor sites on bacterial cells.
Reported Benefits (Provisional)
Origin & History
D-Mannose is a simple sugar found naturally in fruits like cranberries, apples, and peaches. It is extracted and purified for use in supplements, often through crystallization processes.
Research Narrative (Provisional)
RCTs and clinical trials support its efficacy in reducing UTI recurrence. It is well-documented for urinary tract health.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Simple sugar with prebiotic properties. - Low-calorie sweetener. - Provides urinary tract health benefits.
Reported Mechanism (Provisional)
D-mannose binds to FimH adhesins on E. coli bacteria with higher affinity than uroepithelial cells, preventing bacterial attachment to bladder and urinary tract walls. The sugar is rapidly absorbed and excreted unchanged through urine, maintaining therapeutic concentrations in the urinary tract. This competitive inhibition mechanism allows existing bacteria to be flushed out naturally during urination.
Clinical Narrative (Provisional)
Randomized controlled trials involving 308 women showed D-mannose reduced UTI recurrence by 45-58% compared to placebo over 6-month periods. A 2014 study found 2 grams daily was as effective as nitrofurantoin antibiotic for UTI prevention. Multiple clinical trials demonstrate efficacy primarily against E. coli infections, which cause 80-90% of uncomplicated UTIs. Evidence is strongest for prevention in recurrent UTI patients, with limited data on acute treatment effectiveness.
Also Known As
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